Discovery of 2-hydroxyarbekacin, a new aminoglycoside antibiotic with reduced nephrotoxicity

Discovery of 2-hydroxyarbekacin, a new aminoglycoside antibiotic with reduced nephrotoxicity

The Journal of Antibiotics advance online publication, June 28 2017. doi:10.1038/ja.2017.60

Authors: Yoshiaki Takahashi, Eijiro Umemura, Yoshihiko Kobayashi, Shoichi Murakami, Toru Nawa, Akihiro Morinaka, Toshiaki Miyake & Masakatsu Shibasaki

from The Journal of Antibiotics - AOP - nature.com science feeds http://ift.tt/2skYg6L

A 2,4′-linked tetrahydroxanthone dimer with protein tyrosine phosphatase 1B inhibitory activity from the Okinawan freshwater Aspergillus sp.

A 2,4′-linked tetrahydroxanthone dimer with protein tyrosine phosphatase 1B inhibitory activity from the Okinawan freshwater Aspergillus sp.

The Journal of Antibiotics advance online publication, June 28 2017. doi:10.1038/ja.2017.72

Authors: Henki Rotinsulu, Hiroyuki Yamazaki, Tomohito Miura, Satomi Chiba, Defny S Wewengkang, Deiske A Sumilat & Michio Namikoshi

from The Journal of Antibiotics - AOP - nature.com science feeds http://ift.tt/2skQM3E

Antimicrobial sulfonamides clear latent Kaposi sarcoma herpesvirus infection and impair MDM2–p53 complex formation

Antimicrobial sulfonamides clear latent Kaposi sarcoma herpesvirus infection and impair MDM2–p53 complex formation

The Journal of Antibiotics advance online publication, June 14 2017. doi:10.1038/ja.2017.67

Authors: Fabrizio Angius, Enrica Piras, Sabrina Uda, Clelia Madeddu, Roberto Serpe, Rachele Bigi, Wuguo Chen, Dirk P Dittmer, Raffaello Pompei & Angela Ingianni

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A three-component coupling approach to the ACE-ring substructure of C19-diterpene alkaloids

A three-component coupling approach to the ACE-ring substructure of C19-diterpene alkaloids

The Journal of Antibiotics advance online publication, June 14 2017. doi:10.1038/ja.2017.69

Authors: Kosuke Minagawa, Daisuke Urabe & Masayuki Inoue

from The Journal of Antibiotics - AOP - nature.com science feeds http://ift.tt/2smUvBq

A novel polycyclic meroterpenoid with aldose reductase inhibitory activity from medicinal mushroom Ganoderma leucocontextum

A novel polycyclic meroterpenoid with aldose reductase inhibitory activity from medicinal mushroom Ganoderma leucocontextum

The Journal of Antibiotics advance online publication, May 24 2017. doi:10.1038/ja.2017.57

Authors: Jinjin Zhang, Ke Ma, Hongyu Chen, Kai Wang, Weiping Xiong, Li Bao & Hongwei Liu

from The Journal of Antibiotics - AOP - nature.com science feeds http://ift.tt/2rP0bRU

Nutritional control of antibiotic production by Streptomyces platensis MA7327: importance of l-aspartic acid

Nutritional control of antibiotic production by Streptomyces platensis MA7327: importance of l-aspartic acid

The Journal of Antibiotics advance online publication, May 3 2017. doi:10.1038/ja.2017.49

Authors: Maria Falzone, Emmanuel Crespo, Klarissa Jones, Gulaba Khan, Victoria L Korn, Amreen Patel, Mira Patel, Krishnaben Patel, Carrie Perkins, Sana Siddiqui, Drew Stenger, Eileen Yu, Michael Gelber, Robert Scheffler, Vasyl Nayda, Ariela Ravin, Ronica Komal, Jeffrey D Rudolf, Ben Shen, Vincent Gullo & Arnold L Demain

from The Journal of Antibiotics - AOP - nature.com science feeds http://ift.tt/2pveMD6

New chlorinated xanthone and anthraquinone produced by a mangrove-derived fungus Penicillium citrinum HL-5126

New chlorinated xanthone and anthraquinone produced by a mangrove-derived fungus Penicillium citrinum HL-5126

The Journal of Antibiotics advance online publication, May 3 2017. doi:10.1038/ja.2017.52

Authors: Ke-Yao He, Cheng Zhang, Yi-Ru Duan, Guo-Lei Huang, Chun-Yan Yang, Xing-Rui Lu, Cai-Juan Zheng & Guang-Ying Chen

from The Journal of Antibiotics - AOP - nature.com science feeds http://ift.tt/2pvsvtv