mardi 30 juin 2015

Distribution and isolation of strains belonging to the order Solirubrobacterales

Distribution and isolation of strains belonging to the order Solirubrobacterales

The Journal of Antibiotics advance online publication, July 1 2015. doi:10.1038/ja.2015.67

Authors: Tamae Seki, Atsuko Matsumoto, Satoshi Ōmura & Yōko Takahashi



from The Journal of Antibiotics - AOP - nature.com science feeds http://ift.tt/1Kq0RBC

Genome-based analysis of type-I polyketide synthase and nonribosomal peptide synthetase gene clusters in a novel strain taxonomically close to the genus Salinispora

Genome-based analysis of type-I polyketide synthase and nonribosomal peptide synthetase gene clusters in a novel strain taxonomically close to the genus Salinispora

The Journal of Antibiotics advance online publication, July 1 2015. doi:10.1038/ja.2015.69

Authors: Hisayuki Komaki, Tomohiko Tamura, Natsuko Ichikawa, Akio Oguchi, Moriyuki Hamada, Ken-ichiro Suzuki & Nobuyuki Fujita



from The Journal of Antibiotics - AOP - nature.com science feeds http://ift.tt/1dwawtp

Cytosine-type nucleosides from marine-derived Streptomyces rochei 06CM016

Cytosine-type nucleosides from marine-derived Streptomyces rochei 06CM016

The Journal of Antibiotics advance online publication, July 1 2015. doi:10.1038/ja.2015.72

Authors: Semiha Çetinel Aksoy, Ataç Uzel & Erdal Bedir



from The Journal of Antibiotics - AOP - nature.com science feeds http://ift.tt/1dwawth

An overproduction of astellolides induced by genetic disruption of chromatin-remodeling factors in Aspergillus oryzae

An overproduction of astellolides induced by genetic disruption of chromatin-remodeling factors in Aspergillus oryzae

The Journal of Antibiotics advance online publication, July 1 2015. doi:10.1038/ja.2015.73

Authors: Yasutomo Shinohara, Makoto Kawatani, Yushi Futamura, Hiroyuki Osada & Yasuji Koyama



from The Journal of Antibiotics - AOP - nature.com science feeds http://ift.tt/1Kq0SFH

mardi 23 juin 2015

Development of a multiplex PCR system and its application in detection of blaSHV, blaTEM, blaCTX-M-1, blaCTX-M-9 and blaOXA-1 group genes in clinical Klebsiella pneumoniae and Escherichia coli strains

Development of a multiplex PCR system and its application in detection of blaSHV, blaTEM, blaCTX-M-1, blaCTX-M-9 and blaOXA-1 group genes in clinical Klebsiella pneumoniae and Escherichia coli strains

The Journal of Antibiotics advance online publication, June 24 2015. doi:10.1038/ja.2015.68

Authors: James O Ogutu, Qingmeng Zhang, Ying Huang, Huo Yan, Lijie Su, Bo Gao, Wenli Zhang, Jizi Zhao, Wenhui Cai, Wenjing Li, Hong Zhao, Yang Chen, Wuqi Song, Xiaobei Chen, Yingmei Fu & Fengmin Zhang



from The Journal of Antibiotics - AOP - nature.com science feeds http://ift.tt/1HeYNeO

Xiakemycin A, a novel pyranonaphthoquinone antibiotic, produced by the Streptomyces sp. CC8-201 from the soil of a karst cave

Xiakemycin A, a novel pyranonaphthoquinone antibiotic, produced by the Streptomyces sp. CC8-201 from the soil of a karst cave

The Journal of Antibiotics advance online publication, June 24 2015. doi:10.1038/ja.2015.70

Authors: Zhong-ke Jiang, Lin Guo, Chuan Chen, Shao-wei Liu, Lin Zhang, Su-juan Dai, Qi-yang He, Xue-fu You, Xin-xin Hu, Li Tuo, Wei Jiang & Cheng-hang Sun



from The Journal of Antibiotics - AOP - nature.com science feeds http://ift.tt/1HeYMYm

lundi 15 juin 2015

Antimicrobial stewardship: the role of scientists?

We continue to be warned about the risk of antibiotic resistance. This campaign has targeted medicine and agriculture, asking these industries to pay attention to the risks of widespread resistance and to cut the use of antibiotics wherever possible. However, there has been little to no mention of the widespread use of antibiotics in the scientific research community. As scientists we use antibiotics and antibiotic resistance as fundamental tools for our research; almost all conventional plasmids use an antibiotic resistance gene as a selectable marker, offering us an easy method of screening. With molecular biology and genetics at the heart of many research disciplines, these tools are ubiquitous. Scientists have a responsibility to monitor and reduce our use of antibiotics. With the growth and fast advancement of synthetic biology, it is timely for us to consider other options and to teach the next generation of researchers by example how to truly value antibiotics by using them more responsibly.



from Journal of Antimicrobial Chemotherapy - current issue http://ift.tt/1KU2oAw
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Is infant exposure to antiretroviral drugs during breastfeeding quantitatively important? A systematic review and meta-analysis of pharmacokinetic studies

A vanG-type locus in Clostridium argentinense

Multiple mutations and increased RNA expression in tetracycline-resistant Streptococcus pneumoniae as determined by genome-wide DNA and mRNA sequencing

Assessment of multidrug resistance, clonality and virulence in non-PCV-13 Streptococcus pneumoniae serotypes in Canada, 2011-13

Investigation of a possible outbreak of carbapenem-resistant Acinetobacter baumannii in Odense, Denmark using PFGE, MLST and whole-genome-based SNPs

Third-generation cephalosporin resistance conferred by a chromosomally encoded blaCMY-23 gene in the Escherichia coli ST131 reference strain EC958

Description of IMP-31, a novel metallo-{beta}-lactamase found in an ST235 Pseudomonas aeruginosa strain in Western Germany

Survey of metallo-{beta}-lactamase-producing Enterobacteriaceae colonizing patients in European ICUs and rehabilitation units, 2008-11

Metagenomic analysis of the impact of nitrofurantoin treatment on the human faecal microbiota

The Rpd3/Hda1 family of histone deacetylases regulates azole resistance in Candida albicans

Influenza viruses with B/Yamagata- and B/Victoria-like neuraminidases are differentially affected by mutations that alter antiviral susceptibility

A novel small-molecule inhibitor of hepatitis C virus replication acts by suppressing signal transducer and activator of transcription 3

Worldwide distribution of the NS3 gene 80K polymorphism among circulating hepatitis C genotype 1 viruses: implication for simeprevir usage

Bactericidal mode of action of bedaquiline

Challenges to accurate susceptibility testing and interpretation of quinolone resistance in Enterobacteriaceae: results of a Spanish multicentre study

Susceptibility in vitro of canine methicillin-resistant and -susceptible staphylococcal isolates to fusidic acid, chlorhexidine and miconazole: opportunities for topical therapy of canine superficial pyoderma

Activity of ceftaroline and comparator agents tested against Staphylococcus aureus from patients with bloodstream infections in US medical centres (2009-13)

Antibiotic penetration and bacterial killing in a Pseudomonas aeruginosa biofilm model

Vancomycin serum concentrations do not adequately predict tissue exposure in diabetic patients with mild to moderate limb infections

Optimal timing of oral fosfomycin administration for pre-prostate biopsy prophylaxis

Novel model-based dosing guidelines for gentamicin and tobramycin in preterm and term neonates

Lack of a significant pharmacokinetic interaction between maraviroc and tacrolimus in allogeneic HSCT recipients

HIV-1 subtype B-infected MSM may have driven the spread of transmitted resistant strains in France in 2007-12: impact on susceptibility to first-line strategies

Highly frequent HIV-1 minority resistant variants at baseline of the ANRS 139 TRIO trial had a limited impact on virological response

Reductions in virological failure and drug resistance in Chinese antiretroviral-treated patients due to lamivudine-based regimens, 2003-12

Switching from tenofovir to abacavir in HIV-1-infected patients with low bone mineral density: changes in bone turnover markers and circulating sclerostin levels

Combined ART started during acute HIV infection protects central memory CD4+ T cells and can induce remission

Persistence and adherence to single-tablet regimens in HIV treatment: a cohort study from the French National Healthcare Insurance Database

IFN-{alpha}2a or IFN-{beta}1a in combination with ribavirin to treat Middle East respiratory syndrome coronavirus pneumonia: a retrospective study

mercredi 10 juin 2015

Phenylpyropenes E and F: new meroterpenes from the marine-derived fungus Penicillium concentricum ZLQ-69

Phenylpyropenes E and F: new meroterpenes from the marine-derived fungus Penicillium concentricum ZLQ-69

The Journal of Antibiotics advance online publication, June 10 2015. doi:10.1038/ja.2015.64

Authors: Zhuang Ding, Lianqing Zhang, Juan Fu, Qian Che, Dehai Li, Qianqun Gu & Tianjiao Zhu



from The Journal of Antibiotics - AOP - nature.com science feeds http://ift.tt/1FIjP13

New ansamycin analogues from the mutant strain of Streptomyces seoulensis

New ansamycin analogues from the mutant strain of Streptomyces seoulensis

The Journal of Antibiotics advance online publication, June 10 2015. doi:10.1038/ja.2015.65

Authors: Ya-Nan Song, Wen-Jing Zhang, Shu-Feng Bi, Rui-Hua Jiao, Ren-Xiang Tan & Hui-Ming Ge



from The Journal of Antibiotics - AOP - nature.com science feeds http://ift.tt/1FIjP0Y

A new sarkomycin analog from Streptomyces sp. HS-HY-144

A new sarkomycin analog from Streptomyces sp. HS-HY-144

The Journal of Antibiotics advance online publication, June 10 2015. doi:10.1038/ja.2015.66

Authors: Li-fei Liu, Huan Qi, Hui Zhang, Ji-dong Wang & Nie-fang Yu



from The Journal of Antibiotics - AOP - nature.com science feeds http://ift.tt/1FIjQSR