Endophytic fungal compounds active against Cryptococcus neoformans and C. gattii

Endophytic fungal compounds active against Cryptococcus neoformans and C. gattii

The Journal of Antibiotics advance online publication, February 25 2015. doi:10.1038/ja.2015.11

Authors: Cristiane B Pereira, Djalma M de Oliveira, Alice FS Hughes, Markus Kohlhoff, Mariana LA Vieira, Aline B Martins Vaz, Mariana C Ferreira, Camila R Carvalho, Luiz H Rosa, Carlos A Rosa, Tânia MA Alves, Carlos L Zani, Susana Johann & Betania B Cota

from The Journal of Antibiotics - AOP - nature.com science feeds http://ift.tt/1GslXM3

Coculnol, a new penicillic acid produced by a coculture of Fusarium solani FKI-6853 and Talaromyces sp. FKA-65

Coculnol, a new penicillic acid produced by a coculture of Fusarium solani FKI-6853 and Talaromyces sp. FKA-65

The Journal of Antibiotics advance online publication, February 25 2015. doi:10.1038/ja.2015.15

Authors: Kenichi Nonaka, Takuya Chiba, Takuya Suga, Yukihiro Asami, Masato Iwatsuki, Rokuro Masuma, Satoshi Ōmura & Kazuro Shiomi

from The Journal of Antibiotics - AOP - nature.com science feeds http://ift.tt/1GslZUl

Two new stemphol sulfates from the mangrove endophytic fungus Stemphylium sp. 33231

Two new stemphol sulfates from the mangrove endophytic fungus Stemphylium sp. 33231

The Journal of Antibiotics advance online publication, February 25 2015. doi:10.1038/ja.2015.16

Authors: Xue-Ming Zhou, Cai-Juan Zheng, Guang-Ying Chen, Xiao-Ping Song, Chang-Ri Han, Xiong-Zhao Tang, Rui-Jie Liu & Li-Lian Ren

from The Journal of Antibiotics - AOP - nature.com science feeds http://ift.tt/1BqEJoF

The stereostructure of candicidin D

The stereostructure of candicidin D

The Journal of Antibiotics advance online publication, February 25 2015. doi:10.1038/ja.2015.17

Authors: Katarzyna Szwarc, Paweł Szczeblewski, Paweł Sowiński, Edward Borowski & Jan Pawlak

from The Journal of Antibiotics - AOP - nature.com science feeds http://ift.tt/1GslZDD

Novel thioviridamide derivative—JBIR-140: heterologous expression of the gene cluster for thioviridamide biosynthesis

Novel thioviridamide derivative—JBIR-140: heterologous expression of the gene cluster for thioviridamide biosynthesis

The Journal of Antibiotics advance online publication, February 25 2015. doi:10.1038/ja.2015.20

Authors: Miho Izumikawa, Ikuko Kozone, Junko Hashimoto, Noritaka Kagaya, Motoki Takagi, Hanae Koiwai, Mamoru Komatsu, Manabu Fujie, Noriyuki Satoh, Haruo Ikeda & Kazuo Shin-ya

from The Journal of Antibiotics - AOP - nature.com science feeds http://ift.tt/1BqEIRL

Penicillimide, an open-chain hemisuccinimide from Okinawan marine-derived Penicillium copticola

Penicillimide, an open-chain hemisuccinimide from Okinawan marine-derived Penicillium copticola

The Journal of Antibiotics advance online publication, February 25 2015. doi:10.1038/ja.2015.21

Authors: Ying-Yue Bu, Hiroyuki Yamazaki, Kazuyo Ukai & Michio Namikoshi

from The Journal of Antibiotics - AOP - nature.com science feeds http://ift.tt/1GslZn5

Synthesis and antibacterial activity of 1-N-[(S)-ω-amino-2-hydroxyalkyl] derivatives of dibekacin, 5-deoxydibekacin, 3′-deoxykanamycin A and gentamicin B

Synthesis and antibacterial activity of 1-N-[(S)-ω-amino-2-hydroxyalkyl] derivatives of dibekacin, 5-deoxydibekacin, 3′-deoxykanamycin A and gentamicin B

The Journal of Antibiotics advance online publication, February 25 2015. doi:10.1038/ja.2015.6

Authors: Eijiro Umemura, Yukou Sakamoto, Yoshiaki Takahashi & Toshiaki Miyake

from The Journal of Antibiotics - AOP - nature.com science feeds http://ift.tt/1BqEIkK

Dandamycin and chandrananimycin E, benzoxazines from Streptomyces griseus

Dandamycin and chandrananimycin E, benzoxazines from Streptomyces griseus

The Journal of Antibiotics advance online publication, February 18 2015. doi:10.1038/ja.2015.10

Authors: Emma C Barnes, Patricia Bezerra-Gomes, Markus Nett & Christian Hertweck

from The Journal of Antibiotics - AOP - nature.com science feeds http://ift.tt/19vfa9w

Two herbimycin analogs, 4,5-dihydro-(4S)-4-hydroxyherbimycin B and (15S)-15-hydroxyherbimycin B, from Streptomyces sp. CPCC 200291

Two herbimycin analogs, 4,5-dihydro-(4S)-4-hydroxyherbimycin B and (15S)-15-hydroxyherbimycin B, from Streptomyces sp. CPCC 200291

The Journal of Antibiotics advance online publication, February 18 2015. doi:10.1038/ja.2015.12

Authors: Wei Zhao, Bingya Jiang, Linzhuan Wu, Yanni Nan, Jing Cui, Liyan Yu, Yuzhen Wei, Jinghua Li & Guangzhi Shan

from The Journal of Antibiotics - AOP - nature.com science feeds http://ift.tt/19vf7dR

Structure and biosynthetic implication of 5R-(N-acetyl-L-cysteinyl)-14S-hydroxy-dihydrokalafungin from a mutant of the actVA-ORF4 gene for actinorhodin biosynthesis in Streptomyces coelicolor A3(2)

Structure and biosynthetic implication of 5R-(N-acetyl-L-cysteinyl)-14S-hydroxy-dihydrokalafungin from a mutant of the actVA-ORF4 gene for actinorhodin biosynthesis in Streptomyces coelicolor A3(2)

The Journal of Antibiotics advance online publication, February 18 2015. doi:10.1038/ja.2015.13

Authors: Takaaki Taguchi, Tomoki Maruyama, Ryuichi Sawa, Masayuki Igarashi, Susumu Okamoto & Koji Ichinose

from The Journal of Antibiotics - AOP - nature.com science feeds http://ift.tt/19vf9T6

Identification of novel endophenaside antibiotics produced by Kitasatospora sp. MBT66

Identification of novel endophenaside antibiotics produced by Kitasatospora sp. MBT66

The Journal of Antibiotics advance online publication, February 18 2015. doi:10.1038/ja.2015.14

Authors: Changsheng Wu, Gilles P van Wezel & Young Hae Choi

from The Journal of Antibiotics - AOP - nature.com science feeds http://ift.tt/19vf9SY

Streptosporangium terrae sp. nov., a novel actinomycete isolated from the rhizosphere of Callistemon citrinus (Curtis), India

Streptosporangium terrae sp. nov., a novel actinomycete isolated from the rhizosphere of Callistemon citrinus (Curtis), India

The Journal of Antibiotics advance online publication, February 18 2015. doi:10.1038/ja.2015.5

Authors: Radha Vaddavalli, Bagyanarayana Gaddam & Venkateswar Rao Linga

from The Journal of Antibiotics - AOP - nature.com science feeds http://ift.tt/19vf9SW

Antimalarial activity of kinase inhibitor, nilotinib, in vitro and in vivo

Antimalarial activity of kinase inhibitor, nilotinib, in vitro and in vivo

The Journal of Antibiotics advance online publication, February 18 2015. doi:10.1038/ja.2015.7

Authors: Aki Ishiyama, Masato Iwatsuki, Rei Hokari, Masaaki Sawa, Satoshi Ōmura & Kazuhiko Otoguro

from The Journal of Antibiotics - AOP - nature.com science feeds http://ift.tt/19vf6Xl

Cystodienoic acid: a new diterpene isolated from the myxobacterium Cystobacter sp.

Cystodienoic acid: a new diterpene isolated from the myxobacterium Cystobacter sp.

The Journal of Antibiotics advance online publication, February 18 2015. doi:10.1038/ja.2015.8

Authors: Ritesh Raju, Kathrin I Mohr, Steffen Bernecker, Jennifer Herrmann & Rolf Müller

from The Journal of Antibiotics - AOP - nature.com science feeds http://ift.tt/19vf9CA

Study of efflux pump gene expression in rifampicin-monoresistant Mycobacterium tuberculosis clinical isolates

Study of efflux pump gene expression in rifampicin-monoresistant Mycobacterium tuberculosis clinical isolates

The Journal of Antibiotics advance online publication, February 18 2015. doi:10.1038/ja.2015.9

Authors: Guilian Li, Jingrui Zhang, Qian Guo, Jianhao Wei, Yi Jiang, Xiuqin Zhao, Li-li Zhao, Zhiguang Liu, Jianxin Lu & Kanglin Wan

from The Journal of Antibiotics - AOP - nature.com science feeds http://ift.tt/19vf6GO

Moving forward with reactive oxygen species involvement in antimicrobial lethality

Support for the contribution of reactive oxygen species (ROS) to antimicrobial lethality has been refined and strengthened. Killing by diverse antimicrobials is enhanced by defects in genes that protect against ROS, inhibited by compounds that block hydroxyl radical accumulation, and is associated with surges in intracellular ROS. Moreover, support has emerged for a genetic pathway that controls the level of ROS. Since some antimicrobials kill in the absence of ROS, ROS must add to, rather than replace, known killing mechanisms. New work has addressed many of the questions concerning the specificity of dyes used to detect intracellular ROS and the specificity of perturbations that influence ROS surges. However, complexities associated with killing under anaerobic conditions remain to be resolved. Distinctions among primary lesion formation, resistance, direct lesion-mediated killing and a self-destructive stress response are discussed to facilitate efforts to potentiate ROS-mediated bacterial killing and improve antimicrobial efficacy.

from Journal of Antimicrobial Chemotherapy - current issue http://ift.tt/1IhsvSz

via IFTTT

Daptomycin in paediatrics: current knowledge and the need for future research

To overcome the problems stemming from antimicrobial resistance, there have been several attempts to develop new antimicrobials in recent years. Of the highly potent drugs targeting resistant Gram-positive bacteria, daptomycin has a number of attractive characteristics that suggest its possible use in the treatment of serious infections due to these organisms. Although several pharmacokinetic and clinical studies in adults have provided data to determine how this drug should be prescribed to obtain the maximal clinical efficacy without significant risks of severe adverse events, we have not yet solved all of the problems related to the use of this antibiotic in paediatric patients. In this paper, the resolved and lingering problems of daptomycin treatment in newborns and children are reviewed and discussed. Studies have indicated that daptomycin is a promising therapeutic option for the treatment of paediatric diseases caused by MDR Gram-positive bacilli. However, before daptomycin can be licensed for use in newborns and children, further studies are needed to establish the appropriate dosages for paediatric patients of different ages. The data collected in adults can only be transferred to children older than 12 years, and the information available is not sufficient to determine the dosage that will assure the highest antimicrobial efficacy with only marginal risks of adverse events in younger patients. Thus, studies in neonates and younger infants are urgently needed to permit the use of daptomycin in the first months of life, a period in which infections due to MDR Gram-positive pathogens are increasing.

from Journal of Antimicrobial Chemotherapy - current issue http://ift.tt/1yQwWtO

via IFTTT

Staphylococcus aureus plasmids without mobilization genes are mobilized by a novel conjugative plasmid from community isolates

Characteristics of qacA/B-positive Staphylococcus aureus isolated from patients and a hospital environment in China

Molecular characterization of linezolid-resistant CoNS isolates in Japan

Comparison of an ST80 MRSA strain from the USA with European ST80 strains

Clinically relevant fluoroquinolone resistance due to constitutive overexpression of the PatAB ABC transporter in Streptococcus pneumoniae is conferred by disruption of a transcriptional attenuator

Comprehensive phenotypic characterization of rifampicin resistance mutations in Salmonella provides insight into the evolution of resistance in Mycobacterium tuberculosis

Revisiting susceptibility testing in MDR-TB by a standardized quantitative phenotypic assessment in a European multicentre study

Experimental evidence for IS1294b-mediated transposition of the blaCMY-2 cephalosporinase gene in Enterobacteriaceae

Cephalosporinases associated with outer membrane vesicles released by Bacteroides spp. protect gut pathogens and commensals against {beta}-lactam antibiotics

Development and evaluation of a novel universal {beta}-lactamase gene subtyping assay for blaSHV, blaTEM and blaCTX-M using clinical and livestock-associated Escherichia coli

Manuka honey reduces the motility of Pseudomonas aeruginosa by suppression of flagella-associated genes

NS5A inhibitor resistance-associated polymorphisms in Brazilian treatment-naive patients infected with genotype 1 hepatitis C virus

Impact of the HIV integrase genetic context on the phenotypic expression and in vivo emergence of raltegravir resistance mutations

G118R and F121Y mutations identified in patients failing raltegravir treatment confer dolutegravir resistance

The dual CCR5 and CCR2 inhibitor cenicriviroc does not redistribute HIV into extracellular space: implications for plasma viral load and intracellular DNA decline

Epidemic MRSA clone ST22-IV is more resistant to multiple host- and environment-related stresses compared with ST228-I

Properties and distribution of a metallo-{beta}-lactamase (ALI-1) from the fish pathogen Aliivibrio salmonicida LFI1238

Resistance to and killing by the sporicidal microbicide peracetic acid

Temocillin: a new candidate antibiotic for local antimicrobial delivery in orthopaedic surgery?

Antimicrobial properties of liposomal azithromycin for Pseudomonas infections in cystic fibrosis patients

Ceftaroline fosamil salvage therapy: an option for reduced-vancomycin-susceptible MRSA bacteraemia

Antifungal susceptibilities of Candida glabrata species complex, Candida krusei, Candida parapsilosis species complex and Candida tropicalis causing invasive candidiasis in China: 3 year national surveillance

Time-kill kinetics of antibiotics active against rapidly growing mycobacteria

Shape does matter: short high-concentration exposure minimizes resistance emergence for fluoroquinolones in Pseudomonas aeruginosa

Imaging the distribution of polymyxins in the kidney

Moxifloxacin is not anti-inflammatory in experimental pneumococcal pneumonia

Antifungal activity of 6-quinolinyl N-oxide chalcones against Paracoccidioides

In vivo Candida glabrata biofilm development on foreign bodies in a rat subcutaneous model

Trichoderamides A and B, a pair of stereoisomers from the plant endophytic fungus Trichoderma gamsii

Trichoderamides A and B, a pair of stereoisomers from the plant endophytic fungus Trichoderma gamsii

The Journal of Antibiotics advance online publication, February 4 2015. doi:10.1038/ja.2015.1

Authors: Gang Ding, Lin Chen, Cao Zhou, Jia Hong-Mei, Yue-Tao Liu, Xing Chang, Bo Song, Xing-Zhong Liu, Yu-Cheng Gu & Zhong-Mei Zou

from The Journal of Antibiotics - AOP - nature.com science feeds http://ift.tt/1u6hxJ7

A new antibiotic with potent activity targets MscL

A new antibiotic with potent activity targets MscL

The Journal of Antibiotics advance online publication, February 4 2015. doi:10.1038/ja.2015.4

Authors: Irene Iscla, Robin Wray, Paul Blount, Jonah Larkins-Ford, Annie L Conery, Frederick M Ausubel, Soumya Ramu, Angela Kavanagh, Johnny X Huang, Mark A Blaskovich, Matthew A Cooper, Andres Obregon-Henao, Ian Orme, Edwin S Tjandra, Uwe H Stroeher, Melissa H Brown, Cindy Macardle, Nick van Holst, Chee Ling Tong, Ashley D Slattery, Christopher T Gibson, Colin L Raston & Ramiz A Boulos

from The Journal of Antibiotics - AOP - nature.com science feeds http://ift.tt/1u6hzk0