journal antibiotics: juillet 2015

In the face of increasing antimicrobial resistance and the paucity of new antimicrobial agents it has become clear that new antimicrobial strategies are urgently needed. One of these is to revisit old antibiotics to ensure that they are used correctly and to their full potential, as well as to determine whether one or several of them can help alleviate the pressure on more recent agents. Strategies are urgently needed to ‘re-develop’ these drugs using modern standards, integrating new knowledge into regulatory frameworks and communicating the knowledge from the research bench to the bedside. Without a systematic approach to re-developing these old drugs and rigorously testing them according to today's standards, there is a significant risk of doing harm to patients and further increasing multidrug resistance. This paper describes factors to be considered and outlines steps and actions needed to re-develop old antibiotics so that they can be used effectively for the treatment of infections.

from Journal of Antimicrobial Chemotherapy - current issue http://ift.tt/1HEmCZg
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journal antibiotics

mardi 28 juillet 2015

Phenolic compounds from the fungus Inonotus obliquus and their antioxidant properties

mardi 14 juillet 2015

Biological evaluation and determination of the absolute configuration of chloromonilicin, a strong antimicrobial metabolite isolated from Alternaria sonchi

Three novel polyene macrolides isolated from cultures of Streptomyces lavenduligriseus

lundi 13 juillet 2015

Reviving old antibiotics

A novel gene, optrA, that confers transferable resistance to oxazolidinones and phenicols and its presence in Enterococcus faecalis and Enterococcus faecium of human and animal origin

Within-host diversity of MRSA antimicrobial resistances

Characterization of MDR and XDR Streptococcus pneumoniae in Canada, 2007-13

Prevalence of pilus genes in pneumococci isolated from healthy preschool children in Iceland: association with vaccine serotypes and antibiotic resistance

Retention of virulence following adaptation to colistin in Acinetobacter baumannii reflects the mechanism of resistance

Identification of dfrA14 in two distinct plasmids conferring trimethoprim resistance in Actinobacillus pleuropneumoniae

Emergence and spread of O16-ST131 and O25b-ST131 clones among faecal CTX-M-producing Escherichia coli in healthy individuals in Hunan Province, China

A novel alanine to serine substitution mutation in SoxS induces overexpression of efflux pumps and contributes to multidrug resistance in clinical Escherichia coli isolates

Acquired macrolide resistance genes in Haemophilus influenzae?

Description of an original integron encompassing blaVIM-2, qnrVC1 and genes encoding bacterial group II intron proteins in Pseudomonas aeruginosa

Parallel evolutionary pathways to antibiotic resistance selected by biocide exposure

Efavirenz alters mitochondrial respiratory function in cultured neuron and glial cell lines

Antimicrobial activity and skin permeation of iodine present in an iodine-impregnated surgical incise drape

Unravelling of a mechanism of resistance to colistin in Klebsiella pneumoniae using atomic force microscopy

Enhanced efficacy of putative efflux pump inhibitor/antibiotic combination treatments versus MDR strains of Pseudomonas aeruginosa in a Galleria mellonella in vivo infection model

Activity of ceftazidime/avibactam against isogenic strains of Escherichia coli containing KPC and SHV {beta}-lactamases with single amino acid substitutions in the ohm-loop

Identification of an anti-TB compound targeting the tyrosyl-tRNA synthetase

The indirect microscopic observation drug susceptibility assay demonstrated high concordance with the indirect MGIT method for pyrazinamide susceptibility testing

Bedaquiline susceptibility testing of Mycobacterium tuberculosis in an automated liquid culture system

Performance of EUCAST and CLSI approaches for co-amoxiclav susceptibility testing conditions for clinical categorization of a collection of Escherichia coli isolates with characterized resistance phenotypes

In vitro activity of surotomycin against contemporary clinical isolates of toxigenic Clostridium difficile strains obtained in Spain

Recurrence of dual-strain Clostridium difficile infection in an in vitro human gut model

Serum and cellular ribavirin pharmacokinetic and concentration-effect analysis in HCV patients receiving sofosbuvir plus ribavirin

Mitochondrial and apoptotic in vitro modelling of differential HIV-1 progression and antiretroviral toxicity

Trends in use of genotypic resistance testing and frequency of major drug resistance among antiretroviral-naive persons in the HIV Outpatient Study, 1999-2011

Low-level HIV-1 viraemia in patients on HAART: risk factors and management in clinical practice

Candida biomarkers in patients with candidaemia and bacteraemia

The ever-evolving landscape of candidaemia in patients with acute leukaemia: non-susceptibility to caspofungin and multidrug resistance are associated with increased mortality

Can therapeutic drug monitoring optimize exposure to piperacillin in febrile neutropenic patients with haematological malignancies? A randomized controlled trial

mardi 7 juillet 2015

A fluorescence-based bioassay for antibacterials and its application in screening natural product extracts

MBJ-0110, a novel cyclopeptide isolated from the fungus Penicillium sp. f25267