Enantioselective total synthesis of naturally occurring eushearilide and evaluation of its antifungal activity

Enantioselective total synthesis of naturally occurring eushearilide and evaluation of its antifungal activity

The Journal of Antibiotics advance online publication, January 27 2016. doi:10.1038/ja.2015.146

Authors: Takayuki Tonoi, Ryo Kawahara, Takehiko Inohana & Isamu Shiina

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Chemical diversity of labdane-type bicyclic diterpene biosynthesis in Actinomycetales microorganisms

Chemical diversity of labdane-type bicyclic diterpene biosynthesis in Actinomycetales microorganisms

The Journal of Antibiotics advance online publication, January 27 2016. doi:10.1038/ja.2015.147

Authors: Yuuki Yamada, Mamoru Komatsu & Haruo Ikeda

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Synthesis and structure–activity relationship study of FD-891: importance of the side chain and C8–C9 epoxide for cytotoxic activity against cancer cells

Synthesis and structure–activity relationship study of FD-891: importance of the side chain and C8–C9 epoxide for cytotoxic activity against cancer cells

The Journal of Antibiotics advance online publication, January 27 2016. doi:10.1038/ja.2015.148

Authors: Tomohiro Itagaki, Ayano Kawamata, Miho Takeuchi, Keisuke Hamada, Yoshiharu Iwabuchi, Tadashi Eguchi, Fumitaka Kudo, Takeo Usui & Naoki Kanoh

from The Journal of Antibiotics - AOP - nature.com science feeds http://ift.tt/1OOvdiQ

Interaction of the tetracyclines with double-stranded RNAs of random base sequence: new perspectives on the target and mechanism of action

Interaction of the tetracyclines with double-stranded RNAs of random base sequence: new perspectives on the target and mechanism of action

The Journal of Antibiotics advance online publication, January 20 2016. doi:10.1038/ja.2015.145

Authors: Chinwe U Chukwudi & Liam Good

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Synthesis and antibacterial activity of novel lincomycin derivatives. I. Enhancement of antibacterial activities by introduction of substituted azetidines

Synthesis and antibacterial activity of novel lincomycin derivatives. I. Enhancement of antibacterial activities by introduction of substituted azetidines

The Journal of Antibiotics advance online publication, January 13 2016. doi:10.1038/ja.2015.134

Authors: Ko Kumura, Yoshinari Wakiyama, Kazutaka Ueda, Eijiro Umemura, Takashi Watanabe, Eiki Shitara, Hideki Fushimi, Takuji Yoshida & Keiichi Ajito

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Distribution of PASTA domains in penicillin-binding proteins and serine/threonine kinases of Actinobacteria

Distribution of PASTA domains in penicillin-binding proteins and serine/threonine kinases of Actinobacteria

The Journal of Antibiotics advance online publication, January 13 2016. doi:10.1038/ja.2015.138

Author: Hiroshi Ogawara

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Euvesperins A and B, new circumventors of arbekacin resistance in MRSA, produced by Metarhizium sp. FKI-7236

Euvesperins A and B, new circumventors of arbekacin resistance in MRSA, produced by Metarhizium sp. FKI-7236

The Journal of Antibiotics advance online publication, January 13 2016. doi:10.1038/ja.2015.140

Authors: Mayu Shiina, Takuya Suga, Yukihiro Asami, Kenichi Nonaka, Masato Iwatsuki, Satoshi Omura & Kazuro Shiomi

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Aureosurfactin and 3-deoxyaureosurfactin, novel biosurfactants produced by Aureobasidium pullulans L3-GPY

Aureosurfactin and 3-deoxyaureosurfactin, novel biosurfactants produced by Aureobasidium pullulans L3-GPY

The Journal of Antibiotics advance online publication, January 13 2016. doi:10.1038/ja.2015.141

Authors: Jong-Shik Kim, In-Kyoung Lee, Dae-Won Kim & Bong-Sik Yun

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Iminimycin A, the new iminium metabolite produced by Streptomyces griseus OS-3601

Iminimycin A, the new iminium metabolite produced by Streptomyces griseus OS-3601

The Journal of Antibiotics advance online publication, January 13 2016. doi:10.1038/ja.2015.142

Authors: Takuji Nakashima, Rei Miyano, Masato Iwatsuki, Tatsuya Shirahata, Toru Kimura, Yukihiro Asami, Yoshinori Kobayashi, Kazuro Shiomi, George A Petersson, Yōko Takahashi & Satoshi Ōmura

from The Journal of Antibiotics - AOP - nature.com science feeds http://ift.tt/1PapC3t

AN483, a new anti-MRSA compound from Streptomyces sp.

AN483, a new anti-MRSA compound from Streptomyces sp.

The Journal of Antibiotics advance online publication, January 13 2016. doi:10.1038/ja.2015.143

Authors: Yun J Kwon, Mi-Jin Sohn, Hiroyuki Koshino, Chang-Jin Kim & Won-Gon Kim

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Proline-based phosphoramidite reagents for the reductive ligation of S-nitrosothiols

Proline-based phosphoramidite reagents for the reductive ligation of S-nitrosothiols

The Journal of Antibiotics advance online publication, January 13 2016. doi:10.1038/ja.2015.144

Authors: Chung-Min Park, Tyler D Biggs & Ming Xian

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Journal of Antimicrobial Chemotherapy: in the beginning ...

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Antifungal therapy: drug-drug interactions at your fingertips

The Information Age has revolutionized the ability of healthcare professionals (HCPs) to oversee a substantial body of clinically relevant information literally at one's fingertips. In the field of clinical pharmacology, this may be particularly useful for managing drug–drug interactions (DDIs). A thorough understanding of the underlying mechanisms of DDIs allows the HCP to predict such interactions and avoid those of greatest clinical significance. Specifically, successful treatment with antifungal agents is complicated by the high potential to interact with other concomitant medications. We describe here the development of a real-time knowledge base of DDIs with antifungal agents, providing expert recommendations to HCPs on how to handle DDIs with these drugs. This new resource will facilitate rapid identification, quantification and classification of these DDIs by clinicians with varying levels of experience and resources worldwide, ultimately improving patient safety and strengthening health systems.

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The Innovative Medicines Initiative's New Drugs for Bad Bugs programme: European public-private partnerships for the development of new strategies to tackle antibiotic resistance

Antibiotic resistance (ABR) is a global public health threat. Despite the emergence of highly resistant organisms and the huge medical need for new drugs, the development of antibacterials has slowed to an unacceptable level worldwide. Numerous government and non-government agencies have called for public–private partnerships and innovative funding mechanisms to address this problem. To respond to this public health crisis, the Innovative Medicines Initiative Joint Undertaking programme has invested more than 660 million, with a goal of matched contributions from the European Commission and the European Federation of Pharmaceutical Industries and Associations, in the development of new antibacterial strategies. The New Drugs for Bad Bugs (ND4BB) programme, an Innovative Medicines Initiative, has the ultimate goal to boost the fight against ABR at every level from basic science and drug discovery, through clinical development to new business models and responsible use of antibiotics. Seven projects have been launched within the ND4BB programme to achieve this goal. Four of them will include clinical trials of new anti-infective compounds, as well as epidemiological studies on an unprecedented scale, which will increase our knowledge of ABR and specific pathogens, and improve the designs of the clinical trials with new investigational drugs. The need for rapid concerted action has driven the funding of seven topics, each of which should add significantly to progress in the fight against ABR. ND4BB unites expertise and provides a platform where the commitment and resources required by all parties are streamlined into a joint public–private partnership initiative of unprecedented scale.

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Carbapenems versus alternative antibiotics for the treatment of bloodstream infections caused by Enterobacter, Citrobacter or Serratia species: a systematic review with meta-analysis

Characterization of novel conjugative multiresistance plasmids carrying cfr from linezolid-resistant Staphylococcus epidermidis clinical isolates from Italy

Specific gyrA gene mutations predict poor treatment outcome in MDR-TB

Evidence for the critical role of a secondary site rpoB mutation in the compensatory evolution and successful transmission of an MDR tuberculosis outbreak strain

Susceptibility testing breakpoints for Mycobacterium tuberculosis categorize isolates with resistance mutations in gyrA as susceptible to fluoroquinolones: implications for MDR-TB treatment and the definition of XDR-TB

Increase in bacteraemia cases in the East Midlands region of the UK due to MDR Escherichia coli ST73: high levels of genomic and plasmid diversity in causative isolates

Lateral dissemination and inter-patient transmission of blaKPC-3: role of a conjugative plasmid in spreading carbapenem resistance

A single-day point-prevalence study of faecal carriers in long-term care hospitals in Madrid (Spain) depicts a complex clonal and polyclonal dissemination of carbapenemase-producing Enterobacteriaceae

A real-time PCR assay for direct characterization of the Neisseria gonorrhoeae GyrA 91 locus associated with ciprofloxacin susceptibility

Clinical, virological and phylogenetic characterization of a multiresistant HIV-1 strain outbreak in naive patients in southern Spain

Deep analysis of HIV-1 natural variability across HIV-1 variants at residues associated with integrase inhibitor (INI) resistance in INI-naive individuals

Factors influencing the efficacy of rilpivirine in HIV-1 subtype C in low- and middle-income countries

Drug transporter gene expression in human colorectal tissue and cell lines: modulation with antiretrovirals for microbicide optimization

Inhibition of herpes simplex virus type 1 by the CDK6 inhibitor PD-0332991 (palbociclib) through the control of SAMHD1

Structural insights into the loss of penicillinase and the gain of ceftazidimase activities by OXA-145 {beta}-lactamase in Pseudomonas aeruginosa

Human oligopeptide transporter 2 (PEPT2) mediates cellular uptake of polymyxins

Searching for new strategies against polymicrobial biofilm infections: guanylated polymethacrylates kill mixed fungal/bacterial biofilms

Resistance patterns in clinical isolates of pathogenic Actinomyces species

Antibacterial activity of achievable epithelial lining fluid exposures of Amikacin Inhale with or without meropenem

Staphylococcus aureus develops increased resistance to antibiotics by forming dynamic small colony variants during chronic osteomyelitis

In vitro and in vivo activity of a novel sorafenib derivative SC5005 against MRSA

Efficacy of dalbavancin in the treatment of MRSA rat sternal osteomyelitis with mediastinitis

Population pharmacokinetics of linezolid in critically ill patients on renal replacement therapy: comparison of equal doses in continuous venovenous haemofiltration and continuous venovenous haemodiafiltration

Pharmacokinetics of vancomycin and dosing recommendations for trauma patients

Placental transfer of the HIV integrase inhibitor dolutegravir in an ex vivo human cotyledon perfusion model

Plasma and intracellular exposure to ganciclovir in adult renal transplant recipients: is there an association with haematological toxicity?

Immunity, inflammation and reservoir in patients at an early stage of HIV infection on intermittent ART (ANRS 141 TIPI Trial)

Isolation of growth inhibitors of the snow rot pathogen Pythium iwayamai from an arctic strain of Trichoderma polysporum

Isolation of growth inhibitors of the snow rot pathogen Pythium iwayamai from an arctic strain of Trichoderma polysporum

The Journal of Antibiotics advance online publication, January 6 2016. doi:10.1038/ja.2015.130

Authors: Miyu Kamo, Motoaki Tojo, Yusuke Yamazaki, Takeshi Itabashi, Hisashi Takeda, Daigo Wakana & Tomoo Hosoe

from The Journal of Antibiotics - AOP - nature.com science feeds http://ift.tt/1S3nTn0

A small-molecule compound belonging to a class of 2,4-disubstituted 1,3,4-thiadiazine-5-ones suppresses Salmonella infection in vivo

A small-molecule compound belonging to a class of 2,4-disubstituted 1,3,4-thiadiazine-5-ones suppresses Salmonella infection in vivo

The Journal of Antibiotics advance online publication, January 6 2016. doi:10.1038/ja.2015.131

Authors: Ludmila N Nesterenko, Nailya A Zigangirova, Egor S Zayakin, Sergey I Luyksaar, Natalie V Kobets, Denis V Balunets, Ludmila A Shabalina, Tatiana N Bolshakova, Olga Y Dobrynina & Alexander L Gintsburg

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Structure and absolute configuration of drimentine I, an alkaloid from Streptomyces sp. CHQ-64

Structure and absolute configuration of drimentine I, an alkaloid from Streptomyces sp. CHQ-64

The Journal of Antibiotics advance online publication, January 6 2016. doi:10.1038/ja.2015.133

Authors: Qian Che, Jing Li, Dehai Li, Qianqun Gu & Tianjiao Zhu

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JBIR-76 and JBIR-77, modified naphthoquinones from Streptomyces sp. RI-77

JBIR-76 and JBIR-77, modified naphthoquinones from Streptomyces sp. RI-77

The Journal of Antibiotics advance online publication, January 6 2016. doi:10.1038/ja.2015.135

Authors: Keiichiro Motohashi, Miho Izumikawa, Noritaka Kagaya, Motoki Takagi & Kazuo Shin-ya

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The Petasis-Ferrier rearrangement: developments and applications

The Petasis-Ferrier rearrangement: developments and applications

The Journal of Antibiotics advance online publication, January 6 2016. doi:10.1038/ja.2015.136

Authors: Emily C Minbiole & Kevin P C Minbiole

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Oxysporizoline, an antibacterial polycyclic quinazoline alkaloid from the marine-mudflat-derived fungus Fusarium oxysporum

Oxysporizoline, an antibacterial polycyclic quinazoline alkaloid from the marine-mudflat-derived fungus Fusarium oxysporum

The Journal of Antibiotics advance online publication, January 6 2016. doi:10.1038/ja.2015.137

Authors: Viviane Nenkep, Keumja Yun & Byeng Wha Son

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