Anti-trypanosomal compound, sagamilactam, a new polyene macrocyclic lactam from Actinomadura sp. K13-0306

Anti-trypanosomal compound, sagamilactam, a new polyene macrocyclic lactam from Actinomadura sp. K13-0306

The Journal of Antibiotics advance online publication, March 30 2016. doi:10.1038/ja.2016.28

Authors: Tōru Kimura, Masato Iwatsuki, Yukihiro Asami, Aki Ishiyama, Rei Hokari, Kazuhiko Otoguro, Atsuko Matsumoto, Noriko Sato, Kazuro Shiomi, Yōko Takahashi, Satoshi Ōmura & Takuji Nakashima

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Anti-Helicobacter pylori activity of some newly synthesized derivatives of xanthone

Anti-Helicobacter pylori activity of some newly synthesized derivatives of xanthone

The Journal of Antibiotics advance online publication, March 30 2016. doi:10.1038/ja.2016.36

Authors: Karolina Klesiewicz, Elżbieta Karczewska, Alicja Budak, Henryk Marona & Natalia Szkaradek

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MIC score, a new tool to compare bacterial susceptibility to antibiotics application to the comparison of susceptibility to different penems of clinical strains of Pseudomonas aeruginosa

MIC score, a new tool to compare bacterial susceptibility to antibiotics application to the comparison of susceptibility to different penems of clinical strains of Pseudomonas aeruginosa

The Journal of Antibiotics advance online publication, March 30 2016. doi:10.1038/ja.2016.38

Authors: Cédric Bretonnière, Adeline Maitte, Jocelyne Caillon, Gilles Potel, David Boutoille, Cédric Jacqueline & Christophe Guitton

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Design and synthesis of 15-deoxyspergualin–biotin conjugates as novel binding probes for target protein screening

Design and synthesis of 15-deoxyspergualin–biotin conjugates as novel binding probes for target protein screening

The Journal of Antibiotics advance online publication, March 23 2016. doi:10.1038/ja.2016.32

Authors: Masahiko Morioka, Kuniki Kato & Kazuo Umezawa

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New conjugates of polyene macrolide amphotericin B with benzoxaboroles: synthesis and properties

New conjugates of polyene macrolide amphotericin B with benzoxaboroles: synthesis and properties

The Journal of Antibiotics advance online publication, March 23 2016. doi:10.1038/ja.2016.34

Authors: Anna N Tevyashova, Alexander M Korolev, Aleksey S Trenin, Lyubov G Dezhenkova, Alexander A Shtil, Vladimir I Polshakov, Oleg Yu Savelyev & Evgenia N Olsufyeva

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Small molecules modulating tumor–stromal cell interactions: new candidates for anti-tumor drugs

Small molecules modulating tumor–stromal cell interactions: new candidates for anti-tumor drugs

The Journal of Antibiotics advance online publication, March 23 2016. doi:10.1038/ja.2016.37

Author: Manabu Kawada

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7-Chlorofolipastatin, an inhibitor of sterol O-acyltransferase, produced by marine-derived Aspergillus ungui NKH-007

7-Chlorofolipastatin, an inhibitor of sterol O-acyltransferase, produced by marine-derived Aspergillus ungui NKH-007

The Journal of Antibiotics advance online publication, March 16 2016. doi:10.1038/ja.2016.27

Authors: Ryuji Uchida, Kento Nakajyo, Keisuke Kobayashi, Taichi Ohshiro, Takeshi Terahara, Chiaki Imada & Hiroshi Tomoda

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Behind the scenes of JAC: the Editorial Office

This brief article takes a look at the work of the JAC Editorial Office and how it contributes to the delivery of JAC to its readers. The article considers how the Editorial Office interacts with authors, referees and Editorial Board members to facilitate the submission, review and final publication of articles.

from Journal of Antimicrobial Chemotherapy - current issue http://ift.tt/1S014hJ
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Personalized medicine for patients with MDR-TB

The emergence of MDR-TB is a cause of great concern due to difficulties in patient management and poor treatment outcomes. Currently the duration of treatment and the choice of drugs for patients with MDR-TB are standardized in many countries. This might not be the best approach since the optimal therapy may depend on different pathogen- and host-related features. Combining the introduction of technological innovations such as whole bacillary genome sequencing for the identification of drug-resistance-associated mutations, therapeutic drug monitoring and host-directed therapies with an individualized approach to MDR-TB management will likely lead to more tolerable, shorter and more efficient treatment regimens and an increase in the quality of life of those affected by MDR-TB.

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Backbones versus core agents in initial ART regimens: one game, two players

The advances seen in ART during the last 30 years have been outstanding. Treatment has evolved from the initial use of single agents as monotherapy. The ability to use HIV RNA as a surrogate marker for clinical outcomes allowed the more rapid evaluation of new therapies. This led to the understanding that triple-drug regimens, including a core agent (an NNRTI or a boosted PI) and two NRTIs, are optimal. These combinations have demonstrated continued improvements in their efficacy and toxicity as initial therapy. However, the need for pharmacokinetic boosting, with potential drug–drug interactions, or residual issues of efficacy or toxicity have persisted for some agents. Most recently, integrase strand transfer inhibitors, particularly dolutegravir, have shown unparalleled safety and efficacy and are currently the core agents of choice. Regimens that included only core agents or only backbone agents have not been as successful as combined therapy in antiretroviral-naive patients. It appears that at least one NRTI is needed for optimal performance and lamivudine and emtricitabine may be the ideal candidates. Several studies are ongoing of agents with longer dosing intervals, lower cost and new NRTI-saving strategies to address unmet needs.

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Ceftaroline fosamil versus ceftriaxone for the treatment of community-acquired pneumonia: individual patient data meta-analysis of randomized controlled trials

Tigecycline resistance in clinical isolates of Enterococcus faecium is mediated by an upregulation of plasmid-encoded tetracycline determinants tet(L) and tet(M)

Comparative analysis of an IncR plasmid carrying armA, blaDHA-1 and qnrB4 from Klebsiella pneumoniae ST37 isolates

Phylogeny, resistome and mobile genetic elements of emergent OXA-48 and OXA-245 Klebsiella pneumoniae clones circulating in Spain

Accurate detection of Neisseria gonorrhoeae ciprofloxacin susceptibility directly from genital and extragenital clinical samples: towards genotype-guided antimicrobial therapy

qnrA6 genetic environment and quinolone resistance conferred on Proteus mirabilis

Genetic characterization of a novel blaDIM-2-carrying megaplasmid p12969-DIM from clinical Pseudomonas putida

1,3-{beta}-D-Glucan contamination of common antimicrobials

The purine analogues abacavir and didanosine increase acetaminophen-induced hepatotoxicity by enhancing mitochondrial dysfunction

Extended-spectrum antibodies protective against carbapenemase-producing Enterobacteriaceae

Covalent immobilization of antimicrobial agents on titanium prevents Staphylococcus aureus and Candida albicans colonization and biofilm formation

Identification and characterization of haemofungin, a novel antifungal compound that inhibits the final step of haem biosynthesis

In vitro combinations of natamycin with voriconazole, itraconazole and micafungin against clinical Fusarium strains causing keratitis

Pentacyclic nitrofurans that rapidly kill nifurtimox-resistant trypanosomes

A multistate tuberculosis pharmacometric model: a framework for studying anti-tubercular drug effects in vitro

Potential of lactoferrin to prevent antibiotic-induced Clostridium difficile infection

Efficacy of vancomycin extended-dosing regimens for treatment of simulated Clostridium difficile infection within an in vitro human gut model

Pharmacodynamics of vancomycin for CoNS infection: experimental basis for optimal use of vancomycin in neonates

Pharmacokinetics and in vivo efficacy of optimized oncocin derivatives

Gentamicin dosing strategy in patients with end-stage renal disease receiving haemodialysis: evaluation using a semi-mechanistic pharmacokinetic/pharmacodynamic model

Simultaneous assessment of the pharmacokinetics of a pleuromutilin, lefamulin, in plasma, soft tissues and pulmonary epithelial lining fluid

Concentrations of tenofovir, lamivudine and efavirenz in mothers and children enrolled under the Option B-Plus approach in Malawi

Dolutegravir and elvitegravir plasma concentrations following cessation of drug intake

Drug-drug interactions between bedaquiline and the antiretrovirals lopinavir/ritonavir and nevirapine in HIV-infected patients with drug-resistant TB

Simulation of the impact of rifampicin on once-daily darunavir/ritonavir pharmacokinetics and dose adjustment strategies: a population pharmacokinetic approach

Dolutegravir-based monotherapy or dual therapy maintains a high proportion of viral suppression even in highly experienced HIV-1-infected patients

Any impact of blips and low-level viraemia episodes among HIV-infected patients with sustained virological suppression on ART?

Studies on novel HIF activators, A-503451s.I. Producing organism, fermentation, isolation and structural elucidation

Studies on novel HIF activators, A-503451s.I. Producing organism, fermentation, isolation and structural elucidation

The Journal of Antibiotics advance online publication, March 9 2016. doi:10.1038/ja.2016.17

Authors: Yuki Hirota-Takahata, Hideki Kobayashi, Masaaki Kizuka, Takao Ohyama, Michiko Kitamura-Miyazaki, Yasuhiro Suzuki, Mie Fujiwara, Mutsuo Nakajima & Osamu Ando

from The Journal of Antibiotics - AOP - nature.com science feeds http://ift.tt/1nvC1s4

Synthesis of the ABCDEF and FGHI ring system of yessotoxin and adriatoxin

Synthesis of the ABCDEF and FGHI ring system of yessotoxin and adriatoxin

The Journal of Antibiotics advance online publication, March 9 2016. doi:10.1038/ja.2016.18

Authors: Yuan Zhang & Jon D Rainier

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Studies on novel HIF activators, A-503451sII: biological activities of A-503451A

Studies on novel HIF activators, A-503451sII: biological activities of A-503451A

The Journal of Antibiotics advance online publication, March 9 2016. doi:10.1038/ja.2016.20

Authors: Hideki Kobayashi, Takao Ohyama, Michiko Kitamura-Miyazaki, Yuki Hirota-Takahata & Osamu Ando

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The use of fluorescently-tagged apoptolidins in cellular uptake and response studies

The use of fluorescently-tagged apoptolidins in cellular uptake and response studies

The Journal of Antibiotics advance online publication, March 9 2016. doi:10.1038/ja.2016.22

Authors: Katherine M Chong, Nalin Leelatian, Sean M Deguire, Asa A Brockman, David Earl, Rebecca A Ihrie, Jonathan M Irish, Brian O Bachmann & Gary A Sulikowski

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Inhibition of protein SUMOylation by natural quinones

Inhibition of protein SUMOylation by natural quinones

The Journal of Antibiotics advance online publication, March 9 2016. doi:10.1038/ja.2016.23

Authors: Isao Fukuda, Mikako Hirohama, Akihiro Ito, Mohammad Tariq, Yasuhiro Igarashi, Hisato Saitoh & Minoru Yoshida

from The Journal of Antibiotics - AOP - nature.com science feeds http://ift.tt/1nvC07o

Furan-iminium cation cyclization (FIC) in a total synthesis of manzamine alkaloids

Furan-iminium cation cyclization (FIC) in a total synthesis of manzamine alkaloids

The Journal of Antibiotics advance online publication, March 9 2016. doi:10.1038/ja.2016.24

Authors: Kazuyuki Tokumaru, Toshiyuki Ohfusa, Shigeru Arai & Atsushi Nishida

from The Journal of Antibiotics - AOP - nature.com science feeds http://ift.tt/1nvC2vX

Synthetic studies toward citrinadin A: construction of the pentacyclic core

Synthetic studies toward citrinadin A: construction of the pentacyclic core

The Journal of Antibiotics advance online publication, March 9 2016. doi:10.1038/ja.2016.25

Authors: Monica E McCallum, Genessa M Smith, Takanori Matsumaru, Ke Kong, John A Enquist Jr & John L Wood

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Pairwise antibiotic interactions in Escherichia coli: triclosan, rifampicin and aztreonam with nine other classes of antibiotics

Pairwise antibiotic interactions in Escherichia coli: triclosan, rifampicin and aztreonam with nine other classes of antibiotics

The Journal of Antibiotics advance online publication, March 9 2016. doi:10.1038/ja.2016.26

Authors: Caroline Nguyen, Alice Zhou, Ayesha Khan, Jeffrey H Miller & Pamela Yeh

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Hangtaimycin, a peptide secondary metabolite discovered from Streptomyces spectabilis CPCC 200148 by chemical screening

Hangtaimycin, a peptide secondary metabolite discovered from Streptomyces spectabilis CPCC 200148 by chemical screening

The Journal of Antibiotics advance online publication, March 9 2016. doi:10.1038/ja.2016.29

Authors: Lijie Zuo, Bingya Jiang, Zhibo Jiang, Wei Zhao, Shufen Li, Hongyu Liu, Bin Hong, Liyan Yu, Limin Zuo & Linzhuan Wu

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Biosynthesis of the α-nitro-containing cyclic tripeptide psychrophilin

Biosynthesis of the α-nitro-containing cyclic tripeptide psychrophilin

The Journal of Antibiotics advance online publication, March 9 2016. doi:10.1038/ja.2016.33

Authors: Muxun Zhao, Hsiao-Ching Lin & Yi Tang

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Synthesis of the phorboxazoles—potent, architecturally novel marine natural products

Synthesis of the phorboxazoles—potent, architecturally novel marine natural products

The Journal of Antibiotics advance online publication, March 9 2016. doi:10.1038/ja.2016.8

Authors: Zachary Shultz & James W Leahy

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In vitro characterization and inhibition of the interaction between ciprofloxacin and berberine against multidrug-resistant Klebsiella pneumoniae

In vitro characterization and inhibition of the interaction between ciprofloxacin and berberine against multidrug-resistant Klebsiella pneumoniae

The Journal of Antibiotics advance online publication, March 2 2016. doi:10.1038/ja.2016.15

Authors: Xiao-Yuan Zhou, Xiao-Guang Ye, Li-Ting He, Su-Rong Zhang, Ruo-Lun Wang, Jun Zhou & Zhuo-Shan He

from The Journal of Antibiotics - AOP - nature.com science feeds http://ift.tt/1QKz52a

Anti-obesity activities of the yoshinone A and the related marine γ-pyrone compounds

Anti-obesity activities of the yoshinone A and the related marine γ-pyrone compounds

The Journal of Antibiotics advance online publication, March 2 2016. doi:10.1038/ja.2016.19

Authors: Tomoyuki Koyama, Yoshinori Kawazoe, Arihiro Iwasaki, Osamu Ohno, Kiyotake Suenaga & Daisuke Uemura

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Organic synthesis in the Smith Group: a personal selection of a dozen lessons learned at the University of Pennsylvania

Organic synthesis in the Smith Group: a personal selection of a dozen lessons learned at the University of Pennsylvania

The Journal of Antibiotics advance online publication, March 2 2016. doi:10.1038/ja.2016.21

Author: Kevin P C Minbiole

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