Cladosporinone, a new viriditoxin derivative from the hypersaline lake derived fungus Cladosporium cladosporioides
The Journal of Antibiotics advance online publication, February 24 2016. doi:10.1038/ja.2016.11
Authors: Yang Liu, Tibor Kurtán, Chang Yun Wang, Wen Han Lin, Raha Orfali, Werner EG Müller, Georgios Daletos & Peter Proksch
Albaflavenoid, a new tricyclic sesquiterpenoid from Streptomyces violascens
The Journal of Antibiotics advance online publication, February 24 2016. doi:10.1038/ja.2016.12
Authors: Dan Zheng, Nan Ding, Yi Jiang, Jiaoyue Zhang, Jian Ma, Xiu Chen, Jiang Liu, Li Han & Xueshi Huang
Syntheses of methylated catechins and theaflavins using 2-nitrobenzenesulfonyl group to protect and deactivate phenol
The Journal of Antibiotics advance online publication, February 24 2016. doi:10.1038/ja.2016.14
Authors: Tomohiro Asakawa, Yusuke Kawabe, Atsushi Yoshida, Yoshiyuki Aihara, Tamiko Manabe, Yoshitsugu Hirose, Asuka Sakurada, Makoto Inai, Yoshitaka Hamashima, Takumi Furuta, Toshiyuki Wakimoto & Toshiyuki Kan
Precursor-directed biosynthesis of new sansanmycin analogs bearing para-substituted-phenylalanines with high yields
The Journal of Antibiotics advance online publication, February 24 2016. doi:10.1038/ja.2016.2
Authors: Ningning Zhang, Li Liu, Guangzhi Shan, Qiang Cai, Xuan Lei, Bin Hong, Linzhuan Wu, Yunying Xie & Ruxian Chen
Effect of different agents with potential antibiofilm activity on antimicrobial susceptibility of biofilms formed by Staphylococcus spp. isolated from implant-related infections
The Journal of Antibiotics advance online publication, February 24 2016. doi:10.1038/ja.2016.9
Authors: Diana Molina-Manso, Gema Del-Prado, Enrique Gómez-Barrena, Jose Cordero-Ampuero, Ricardo Fernandez-Roblas & Jaime Esteban
Genome-based survey of nonribosomal peptide synthetase and polyketide synthase gene clusters in type strains of the genus Microtetraspora
The Journal of Antibiotics advance online publication, February 17 2016. doi:10.1038/ja.2015.139
Authors: Hisayuki Komaki, Natsuko Ichikawa, Tomohiko Tamura, Akio Oguchi, Moriyuki Hamada & Nobuyuki Fujita
Antimicrobial potency of single and combined mupirocin and monoterpenes, thymol, menthol and 1,8-cineole against Staphylococcus aureus planktonic and biofilm growth
The Journal of Antibiotics advance online publication, February 17 2016. doi:10.1038/ja.2016.10
Authors: Domagoj Kifer, Vedran Mužinić & Maja Šegvić Klarić
Total syntheses of codonopsinine and 4-epi-codonopsinine via gold-mediated tandem-catalyzed pyrrole synthesis
The Journal of Antibiotics advance online publication, February 17 2016. doi:10.1038/ja.2016.13
Authors: Minami Yamaguchi, Daichi Itagaki, Hirofumi Ueda & Hidetoshi Tokuyama
Stereoselective access to tubuphenylalanine and tubuvaline: improved Mn-mediated radical additions and assembly of a tubulysin tetrapeptide analog
The Journal of Antibiotics advance online publication, February 17 2016. doi:10.1038/ja.2016.7
Authors: Gregory K Friestad, Koushik Banerjee, Jean-Charles Marié, Umesh Mali & Lei Yao
The enantioselective synthesis and biological evaluation of chimeric promysalin analogs facilitated by diverted total synthesis
The Journal of Antibiotics advance online publication, February 10 2016. doi:10.1038/ja.2016.4
Authors: Kyle W Knouse & William M Wuest
Strategies for construction of the all-carbon macrocyclic skeleton of the ansamycin antibiotic—kendomycin
The Journal of Antibiotics advance online publication, February 10 2016. doi:10.1038/ja.2016.5
Authors: Shu Xu & Hirokazu Arimoto
Practical synthesis of the C-ring precursor of paclitaxel from 3-methoxytoluene
The Journal of Antibiotics advance online publication, February 10 2016. doi:10.1038/ja.2016.6
Authors: Keisuke Fukaya, Yu Yamaguchi, Ami Watanabe, Hiroaki Yamamoto, Tomoya Sugai, Takeshi Sugai, Takaaki Sato & Noritaka Chida
In the genomic era, studying the epidemiology of individual antibiotic resistance genes and resistance gene discovery are open to all. However, the identification and naming of resistance genes is not currently understandable by all owing to a plethora of competing nomenclature systems, many of which do not comply with the basic rules of bacterial gene nomenclature. Change is needed urgently. Here, we make a case for the resistance research community to begin this process by agreeing on an answer to the question of when a new gene number should be assigned. This cut-off is of necessity arbitrary and we suggest a threshold value of ≥2% difference in the sequences of the DNA, predicted protein or both as a realistic boundary for assigning a new gene number. This proposal can be a starting point for agreement or debate followed by renumbering of the affected gene families.
Antimicrobials have been in use for many thousands of years in a variety of formats. In this article, I trace how we have moved from ingenious use of agents available in the environment to chemically engineered agents.
MRSA bacteraemia (MRSAB), including infective endocarditis, carries a high mortality rate, with up to 50% of patients failing initial therapy with vancomycin and requiring salvage therapy. Persistent MRSAB can be difficult to successfully eliminate, especially when source control is not possible due to an irremovable focus or the bacteraemia still persists despite surgical intervention. Although vancomycin and daptomycin are the only two antibiotics approved by the US FDA for the treatment of patients with MRSAB as monotherapy, the employment of novel strategies is required to effectively treat patients with persistent MRSAB and these may frequently involve combination drug therapy. Treatment strategies that are reviewed in this manuscript include vancomycin combined with a β-lactam, daptomycin-based therapy, ceftaroline-based therapy, linezolid-based therapy, quinupristin/dalfopristin, telavancin, trimethoprim/sulfamethoxazole-based therapy and fosfomycin-based therapy. We recommend that combination antibiotic therapy be considered for use in MRSAB salvage treatment.
Hetiamacin B–D, new members of amicoumacin group antibiotics isolated from Bacillus subtilis PJS
The Journal of Antibiotics advance online publication, February 3 2016. doi:10.1038/ja.2016.3
Authors: Shaowei Liu, Xiaoyan Han, Zhongke Jiang, Gang Wu, Xinxin Hu, Xuefu You, Jiandong Jiang, Yubin Zhang & Chenghang Sun
