Synthesis and antibacterial activity of novel lincomycin derivatives. III. Optimization of a phenyl thiadiazole moiety
The Journal of Antibiotics advance online publication, July 5 2017. doi:10.1038/ja.2017.59
Authors: Ko Kumura, Yoshinari Wakiyama, Kazutaka Ueda, Eijiro Umemura, Takashi Watanabe, Mikio Yamamoto, Takuji Yoshida & Keiichi Ajito
A brief history of antibiotics and select advances in their synthesis
The Journal of Antibiotics advance online publication, July 5 2017. doi:10.1038/ja.2017.62
Authors: Kyriacos C Nicolaou & Stephan Rigol
Effect of the meropenem MIC on the killing activity of meropenem and polymyxin B in combination against KPC-producing Klebsiella pneumoniae
The Journal of Antibiotics advance online publication, July 5 2017. doi:10.1038/ja.2017.73
Authors: Brandon Kulengowski, Jeffrey J Campion, David J Feola & David S Burgess
Allantopyrone A interferes with multiple components of the TNF receptor 1 complex and blocks RIP1 modifications in the TNF-α-induced signaling pathway
The Journal of Antibiotics advance online publication, July 5 2017. doi:10.1038/ja.2017.74
Authors: Hue Tu Quach, Riho Tanigaki, Junpei Yokoigawa, Yuriko Yamada, Masamitsu Niwa, Seiya Hirano, Yoshihito Shiono, Ken-ichi Kimura & Takao Kataoka
Trichopeptides A and B, trichocyclodipeptides A–C, new peptides from the ascomycete fungus Stagonospora trichophoricola
The Journal of Antibiotics advance online publication, July 5 2017. doi:10.1038/ja.2017.76
Authors: Zhengkun Chen, Xiuli Xu, Jinwei Ren, Wenzhao Wang, Xingzhong Liu & Erwei Li
Toward the total synthesis of luminamicin; an anaerobic antibiotic: construction of highly functionalized cis-decalin containing a bridged ether moiety
The Journal of Antibiotics advance online publication, July 5 2017. doi:10.1038/ja.2017.77
Authors: Hiroyasu Ando, Aoi Kimishima, Motoyoshi Ohara, Tomoyasu Hirose, Takanori Matsumaru, Hirokazu Takada, Keisuke Morodome, Takehiro Miyamoto, Akihiro Sugawara, Satoshi Ōmura & Toshiaki Sunazuka
Discovery of 2-hydroxyarbekacin, a new aminoglycoside antibiotic with reduced nephrotoxicity
The Journal of Antibiotics advance online publication, June 28 2017. doi:10.1038/ja.2017.60
Authors: Yoshiaki Takahashi, Eijiro Umemura, Yoshihiko Kobayashi, Shoichi Murakami, Toru Nawa, Akihiro Morinaka, Toshiaki Miyake & Masakatsu Shibasaki
A 2,4′-linked tetrahydroxanthone dimer with protein tyrosine phosphatase 1B inhibitory activity from the Okinawan freshwater Aspergillus sp.
The Journal of Antibiotics advance online publication, June 28 2017. doi:10.1038/ja.2017.72
Authors: Henki Rotinsulu, Hiroyuki Yamazaki, Tomohito Miura, Satomi Chiba, Defny S Wewengkang, Deiske A Sumilat & Michio Namikoshi
Antimicrobial sulfonamides clear latent Kaposi sarcoma herpesvirus infection and impair MDM2–p53 complex formation
The Journal of Antibiotics advance online publication, June 14 2017. doi:10.1038/ja.2017.67
Authors: Fabrizio Angius, Enrica Piras, Sabrina Uda, Clelia Madeddu, Roberto Serpe, Rachele Bigi, Wuguo Chen, Dirk P Dittmer, Raffaello Pompei & Angela Ingianni
A three-component coupling approach to the ACE-ring substructure of C19-diterpene alkaloids
The Journal of Antibiotics advance online publication, June 14 2017. doi:10.1038/ja.2017.69
Authors: Kosuke Minagawa, Daisuke Urabe & Masayuki Inoue
A novel polycyclic meroterpenoid with aldose reductase inhibitory activity from medicinal mushroom Ganoderma leucocontextum
The Journal of Antibiotics advance online publication, May 24 2017. doi:10.1038/ja.2017.57
Authors: Jinjin Zhang, Ke Ma, Hongyu Chen, Kai Wang, Weiping Xiong, Li Bao & Hongwei Liu
Nutritional control of antibiotic production by Streptomyces platensis MA7327: importance of l-aspartic acid
The Journal of Antibiotics advance online publication, May 3 2017. doi:10.1038/ja.2017.49
Authors: Maria Falzone, Emmanuel Crespo, Klarissa Jones, Gulaba Khan, Victoria L Korn, Amreen Patel, Mira Patel, Krishnaben Patel, Carrie Perkins, Sana Siddiqui, Drew Stenger, Eileen Yu, Michael Gelber, Robert Scheffler, Vasyl Nayda, Ariela Ravin, Ronica Komal, Jeffrey D Rudolf, Ben Shen, Vincent Gullo & Arnold L Demain
New chlorinated xanthone and anthraquinone produced by a mangrove-derived fungus Penicillium citrinum HL-5126
The Journal of Antibiotics advance online publication, May 3 2017. doi:10.1038/ja.2017.52
Authors: Ke-Yao He, Cheng Zhang, Yi-Ru Duan, Guo-Lei Huang, Chun-Yan Yang, Xing-Rui Lu, Cai-Juan Zheng & Guang-Ying Chen
Synthesis and biological evaluation of indole core-based derivatives with potent antibacterial activity against resistant bacterial pathogens
The Journal of Antibiotics advance online publication, May 3 2017. doi:10.1038/ja.2017.55
Authors: Wei Hong, Jingyang Li, Zhe Chang, Xiaoli Tan, Hao Yang, Yifan Ouyang, Yanhui Yang, Sargit Kaur, Ian C Paterson, Yun Fong Ngeow & Hao Wang
Sonochemical synthesis of pyrido[2,3-d:6,5-d′]-dipyrimidines catalyzed by [HNMP]+[HSO4]− and their antimicrobial activity studies
The Journal of Antibiotics advance online publication, April 26 2017. doi:10.1038/ja.2017.47
Authors: Hossein Naeimi, Asieh Didar, Zahra Rashid & Zohreh Zahraie
Novel antibiotic screening methods to awaken silent or cryptic secondary metabolic pathways in actinomycetes
The Journal of Antibiotics advance online publication, April 26 2017. doi:10.1038/ja.2017.51
Author: Hiroyasu Onaka
Unique prostate cancer-toxic polyketides from marine sediment-derived fungus Isaria felina
The Journal of Antibiotics advance online publication, April 26 2017. doi:10.1038/ja.2017.53
Authors: Olga F Smetanina, Anton N Yurchenko, Elena V Ivanets, Anatoly I Kalinovsky, Yuliya V Khudyakova, Sergey A Dyshlovoy, Gunhild von Amsberg, Ekaterina A Yurchenko & Shamil Sh Afiyatullov
Verification of oligomycin A structure: synthesis and biological evaluation of 33-dehydrooligomycin A
The Journal of Antibiotics advance online publication, April 19 2017. doi:10.1038/ja.2017.48
Authors: Lyudmila N Lysenkova, Oleg Y Saveljev, Natalya E Grammatikova, Vladimir B Tsvetkov, Olga B Bekker, Valery N Danilenko, Lyubov G Dezhenkova, Eugene E Bykov, Olga A Omelchuk, Alexander M Korolev & Andrey E Shchekotikhin
Aurachin SS, a new antibiotic from Streptomyces sp. NA04227
The Journal of Antibiotics advance online publication, April 19 2017. doi:10.1038/ja.2017.50
Authors: Mei Zhang, Cheng Long Yang, Yong Sheng Xiao, Bo Zhang, Xin Zhao Deng, L i Yang, Jing Shi, Y i Shuang Wang, Wei Li, Rui Hua Jiao, Ren Xiang Tan & Hui Ming Ge
Heterologous expression of diverse propionyl-CoA carboxylases affects polyketide production in Escherichia coli
The Journal of Antibiotics advance online publication, April 12 2017. doi:10.1038/ja.2017.38
Authors: Gergana A Vandova, Robert V O'Brien, Brian Lowry, Thomas F Robbins, Curt R Fischer, Ronald W Davis, Chaitan Khosla, Colin JB Harvey & Maureen E Hillenmeyer
In vitro antibacterial activity of MGDG-palmitoyl from Oscillatoria acuminata NTAPC05 against extended-spectrum β-lactamase producers
The Journal of Antibiotics advance online publication, April 5 2017. doi:10.1038/ja.2017.40
Authors: Abdul Azees Parveez Ahamed, Mohammed Uddin Rasheed, Kalilurrahuman Peer Muhamed Noorani, Nazar Reehana, Subramanian Santhoshkumar, Yousuff Mohamed Mohamed Imran, Naiyf S Alharbi, Chinnathambi Arunachalam, Sulaiman Ali Alharbi, Mohammad Abdulkader Akbarsha & Nooruddin Thajuddin
Biochemical characterization of CTX-M-166, a new CTX-M β-lactamase produced by a commensal Escherichia coli isolate
The Journal of Antibiotics advance online publication, April 5 2017. doi:10.1038/ja.2017.42
Authors: Vera Manageiro, Rafael Graça, Eugénia Ferreira, Lurdes Clemente, Richard Bonnet & Manuela Caniça
Formal synthesis of Thienamycin
The Journal of Antibiotics advance online publication, April 5 2017. doi:10.1038/ja.2017.44
Authors: Michał Pieczykolan, Bartłomiej Furman & Marek Chmielewski
Penicillenols from a deep-sea fungus Aspergillus restrictus inhibit Candidaalbicans biofilm formation and hyphal growth
The Journal of Antibiotics advance online publication, April 5 2017. doi:10.1038/ja.2017.45
Authors: Jie Wang, Qi-Feng Yao, Muhammad Amin, Xu-Hua Nong, Xiao-Yong Zhang & Shu-Hua Qi
New diketopiperazine derivatives with cytotoxicity from Nocardiopsis sp. YIM M13066
The Journal of Antibiotics advance online publication, April 5 2017. doi:10.1038/ja.2017.46
Authors: Mingwei Sun, Xiaotong Chen, Wenjun Li, Chunhua Lu & Yuemao Shen
Bioactive secondary metabolites produced by an endophytic fungus Gaeumannomyces sp. JS0464 from a maritime halophyte Phragmites communis
The Journal of Antibiotics advance online publication, March 29 2017. doi:10.1038/ja.2017.39
Authors: Changyeol Lee, Soonok Kim, Wei Li, Sunghee Bang, Hanna Lee, Hyun-Jung Lee, Eun-Young Noh, Jung-Eun Park, Woo Young Bang & Sang Hee Shim
Conjugative ESBL plasmids differ in their potential to rescue susceptible bacteria via horizontal gene transfer in lethal antibiotic concentrations
The Journal of Antibiotics advance online publication, March 29 2017. doi:10.1038/ja.2017.41
Authors: Sari Mattila, Pilvi Ruotsalainen, Ville Ojala, Timo Tuononen, Teppo Hiltunen & Matti Jalasvuori
γ-Ionylidene-type sesquiterpenoids possessing antimicrobial activity against Porphyromonas gingivalis from Phellinus linteus and their absolute structure determination
The Journal of Antibiotics advance online publication, March 22 2017. doi:10.1038/ja.2017.35
Authors: Tatsuya Shirahata, Chieko Ino, Fumi Mizuno, Yoshihisa Asada, Masao Hirotani, George A Petersson, Satoshi Ōmura, Takafumi Yoshikawa & Yoshinori Kobayashi
The master regulator PhoP coordinates phosphate and nitrogen metabolism, respiration, cell differentiation and antibiotic biosynthesis: comparison in Streptomyces coelicolor and Streptomyces avermitilis
The Journal of Antibiotics advance online publication, March 15 2017. doi:10.1038/ja.2017.19
Authors: Juan F Martín, Antonio Rodríguez-García & Paloma Liras
Naphthacemycins, novel circumventors of β-lactam resistance in MRSA, produced by Streptomyces sp. KB-3346-5. I. The taxonomy of the producing strain, and the fermentation, isolation and antibacterial activities
The Journal of Antibiotics advance online publication, March 15 2017. doi:10.1038/ja.2017.28
Authors: Atsushi Fukumoto, Yong-Pil Kim, Atsuko Matsumoto, Yoko Takahashi, Makoto Suzuki, Hideyuki Onodera, Hiroshi Tomoda, Hidehito Matsui, Hideaki Hanaki, Masato Iwatsuki, Satoshi Ōmura & Kazuro Shiomi
Naphthacemycins, novel circumventors of β-lactam resistance in MRSA, produced by Streptomyces sp. KB-3346-5. II. Structure elucidation
The Journal of Antibiotics advance online publication, March 15 2017. doi:10.1038/ja.2017.29
Authors: Atsushi Fukumoto, Yong-Pil Kim, Masato Iwatsuki, Tomoyasu Hirose, Toshiaki Sunazuka, Hideaki Hanaki, Satoshi Ōmura & Kazuro Shiomi
Ivermectin efficacy against Biomphalaria, intermediate host snail vectors of Schistosomiasis
The Journal of Antibiotics advance online publication, March 15 2017. doi:10.1038/ja.2017.31
Authors: Naftale Katz, Neusa Araújo, Paulo Marcos Zech Coelho, Carlos Medicis Morel, Ana Rosa Linde-Arias, Takeshi Yamada, Yuki Horimatsu, Koh Suzuki, Toshiaki Sunazuka & Satoshi Ōmura
Characterization of bafilomycin biosynthesis in Kitasatospora setae KM-6054 and comparative analysis of gene clusters in Actinomycetales microorganisms
The Journal of Antibiotics advance online publication, March 15 2017. doi:10.1038/ja.2017.33
Authors: Ayako Nara, Takuya Hashimoto, Mamoru Komatsu, Makoto Nishiyama, Tomohisa Kuzuyama & Haruo Ikeda
Structure and antibacterial activities of new cyclic peptide antibiotics, pargamicins B, C and D, from Amycolatopsis sp. ML1-hF4
The Journal of Antibiotics advance online publication, March 15 2017. doi:10.1038/ja.2017.34
Authors: Hideki Hashizume, Ryuichi Sawa, Kazuma Yamashita, Yoshio Nishimura & Masayuki Igarashi
Ghanamycins A and B, two novel γ-butyrolactones from marine-derived streptomyces ghanaensis TXC6-16
The Journal of Antibiotics advance online publication, March 15 2017. doi:10.1038/ja.2017.37
Authors: Jia-hui Xu, Kang-bo Gu, Dao-Jing Zhang, Yuan-Guang Li & Li Tian
Trienylfuranol A and trienylfuranone A–B: metabolites isolated from an endophytic fungus, Hypoxylon submoniticulosum, in the raspberry Rubus idaeus
The Journal of Antibiotics advance online publication, March 1 2017. doi:10.1038/ja.2017.18
Authors: Kevin M N Burgess, Ashraf Ibrahim, Dan Sørensen & Mark W Sumarah
Identification of tirandamycins as specific inhibitors of the futalosine pathway
The Journal of Antibiotics advance online publication, March 1 2017. doi:10.1038/ja.2017.22
Authors: Yasushi Ogasawara, Kensuke Kondo, Ayumi Ikeda, Rikako Harada & Tohru Dairi
Incubation of 2-methylisoborneol synthase with the intermediate analog 2-methylneryl diphosphate
The Journal of Antibiotics advance online publication, March 1 2017. doi:10.1038/ja.2017.24
Authors: Wayne KW Chou, Colin A Gould & David E Cane
Fradiamine A, a new siderophore from the deep-sea actinomycete Streptomyces fradiae MM456M-mF7
The Journal of Antibiotics advance online publication, March 1 2017. doi:10.1038/ja.2017.26
Authors: Yasuhiro Takehana, Maya Umekita, Masaki Hatano, Chiaki Kato, Ryuichi Sawa & Masayuki Igarashi
The antibiotic resistance crisis, with a focus on the United States
The Journal of Antibiotics advance online publication, March 1 2017. doi:10.1038/ja.2017.30
Authors: Evan Martens & Arnold L Demain
Molecular epigenetic approach activates silent gene cluster producing dimeric bis-spiro-azaphilones in Chaetomium globosum CBS148.51
The Journal of Antibiotics advance online publication, March 1 2017. doi:10.1038/ja.2017.4
Authors: Meng-Hua Wang, Tao Jiang, Gang Ding, Shu-Bin Niu, Xue-Wei Wang, Meng Yu, Yu-Cheng Gu, Qiu-Bo Zhang, Jia-Huan Chen, Hong-Mei Jia & Zhong-Mei Zou
Development of a new air-stable structure-simplified nafuredin-γ analog as a potent and selective nematode complex I inhibitor
The Journal of Antibiotics advance online publication, February 22 2017. doi:10.1038/ja.2017.16
Authors: Masaki Ohtawa, Shiho Arima, Risa Shimizu, Naomi Hanatani, Eri Shimizu, Kazuro Shiomi, Kiyoshi Kita, Satoshi Ōmura & Tohru Nagamitsu
Cytotoxic rearranged angucycline glycosides from deep sea-derived Streptomyces lusitanus SCSIO LR32
The Journal of Antibiotics advance online publication, February 22 2017. doi:10.1038/ja.2017.17
Authors: Xiangcheng Zhu, Yanwen Duan, Zhaomeng Cui, Zhen Wang, Zengxia Li, Yun Zhang, Jianhua Ju & Hongbo Huang
The efficacy of different anti-microbial metals at preventing the formation of, and eradicating bacterial biofilms of pathogenic indicator strains
The Journal of Antibiotics advance online publication, February 15 2017. doi:10.1038/ja.2017.10
Authors: Natalie Gugala, Joe A Lemire & Raymond J Turner
Ivermectin: enigmatic multifaceted ‘wonder’ drug continues to surprise and exceed expectations
The Journal of Antibiotics advance online publication, February 15 2017. doi:10.1038/ja.2017.11
Author: Andy Crump
Biosynthetic studies on terpenoids produced by Streptomyces
The Journal of Antibiotics advance online publication, February 15 2017. doi:10.1038/ja.2017.12
Author: Tomohisa Kuzuyama
Competition and co-regulation of spirotoamide and tautomycetin biosynthesis in Streptomyces griseochromogenes, and isolation and structural elucidation of spirotoamide C and D
The Journal of Antibiotics advance online publication, February 15 2017. doi:10.1038/ja.2017.13
Authors: Dong Yang, Mostafa E Rateb, Nan Wang & Ben Shen
Acremopeptin, a new peptaibol from Acremonium sp. PF1450
The Journal of Antibiotics advance online publication, February 15 2017. doi:10.1038/ja.2017.15
Authors: Masatomi Iijima, Masahide Amemiya, Ryuichi Sawa, Yumiko Kubota, Takao Kunisada, Isao Momose, Manabu Kawada & Masakatsu Shibasaki
Two new polyketides from the ascomycete fungus Leptosphaeria sp.
The Journal of Antibiotics advance online publication, February 15 2017. doi:10.1038/ja.2017.5
Authors: Jie Lin, Renlei Wang, Guohua Xu, Zhengfeng Ding, Xueshen Zhu, Erwei Li & Ling Liu
Synergistic effects of vancomycin and β-lactams against vancomycin highly resistant Staphylococcus aureus
The Journal of Antibiotics advance online publication, February 15 2017. doi:10.1038/ja.2017.7
Authors: Fumiaki Tabuchi, Yasuhiko Matsumoto, Masaki Ishii, Keita Tatsuno, Mitsuhiro Okazaki, Tomoaki Sato, Kyoji Moriya & Kazuhisa Sekimizu
