Isolation and identification of new macrocyclic lactones from a genetically engineered strain Streptomyces bingchenggensis BCJ60

Isolation and identification of new macrocyclic lactones from a genetically engineered strain Streptomyces bingchenggensis BCJ60

The Journal of Antibiotics advance online publication, October 26 2016. doi:10.1038/ja.2016.130

Authors: Jiansong Li, Shaoyong Zhang, Hui Zhang, Haiyan Wang, Ji Zhang, Anliang Chen, Jidong Wang & Wensheng Xiang

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Contribution of JAC to antimicrobial stewardship

Antimicrobial stewardship programmes are increasingly being used to improve the quality of antimicrobial prescribing, with the dual aim of optimizing clinical outcomes and minimizing the emergence and spread of antimicrobial resistance. The Journal of Antimicrobial Chemotherapy (JAC) is celebrating its 40th anniversary and, as part of activities to commemorate this event, this article highlights the contribution of JAC to antimicrobial stewardship. Papers published in JAC have contributed to the evidence base for stewardship, have highlighted educational and behavioural change initiatives aimed at improving antibiotic prescribing practice, and have actively sought to foster the practice of antimicrobial stewardship amongst its readers.

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Pharmacodynamics for antifungal drug development: an approach for acceleration, risk minimization and demonstration of causality

The treatment of invasive fungal diseases constitutes a significant unmet medical need. There are relatively few antifungal agents in clinical development and a paucity of novel targets. Morbidity and mortality remain high and clinical outcomes are compromised by submaximal efficacy, emergence of drug resistance and drug-related toxicity. Thus, new antifungal agents are urgently required. A deep understanding of exposure–response relationships underpins the development of safe and effective clinical regimens of any therapeutic agent. Pharmacokinetics (PK) and pharmacodynamics (PD) is increasingly recognized as a vital tool in the development of new antimicrobial agents and maximizes the probability that the right dose will be studied the first time. There is currently no information or agreement as to what constitutes an adequate PK/PD package for the development of a new antifungal agent. This review provides a summary of the achievements of antifungal PK/PD for the treatment of invasive candidiasis, invasive aspergillosis and cryptococcal meningoencephalitis, and outlines the necessary components of a PK/PD package for a new antifungal agent. Such information is critical for the accelerated and efficient development of new agents and enables improved clinical outcomes to be secured.

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Therapeutic drug monitoring of vancomycin: a guideline of the Division of Therapeutic Drug Monitoring, Chinese Pharmacological Society

Antimicrobial stewardship in wound care: a Position Paper from the British Society for Antimicrobial Chemotherapy and European Wound Management Association

Impact on antiviral resistance of E119V, I222L and R292K substitutions in influenza A viruses bearing a group 2 neuraminidase (N2, N3, N6, N7 and N9)

Novel chromosome-encoded erm(47) determinant responsible for constitutive MLSB resistance in Helcococcus kunzii

Identification of non-PBP2a resistance mechanisms in Staphylococcus aureus after serial passage with ceftaroline: involvement of other PBPs

Cluster-dependent colistin hetero-resistance in Enterobacter cloacae complex

Molecular characterization of blaESBL-producing Escherichia coli cultured from pig farms in Ireland

Impact of AAC(6')-Ib-cr in combination with chromosomal-mediated mechanisms on clinical quinolone resistance in Escherichia coli

Bacteriophage LM33_P1, a fast-acting weapon against the pandemic ST131-O25b:H4 Escherichia coli clonal complex

Tracking inter-institutional spread of NDM and identification of a novel NDM-positive plasmid, pSg1-NDM, using next-generation sequencing approaches

Real-time PCR detection of Neisseria gonorrhoeae susceptibility to penicillin

The novel 2016 WHO Neisseria gonorrhoeae reference strains for global quality assurance of laboratory investigations: phenotypic, genetic and reference genome characterization

WGS analysis and molecular resistance mechanisms of azithromycin-resistant (MIC >2 mg/L) Neisseria gonorrhoeae isolates in Europe from 2009 to 2014

Use of WGS data for investigation of a long-term NDM-1-producing Citrobacter freundii outbreak and secondary in vivo spread of blaNDM-1 to Escherichia coli, Klebsiella pneumoniae and Klebsiella oxytoca

Positive regulation of the Candida albicans multidrug efflux pump Cdr1p function by phosphorylation of its N-terminal extension

Dose optimization of voriconazole/anidulafungin combination against Aspergillus fumigatus using an in vitro pharmacokinetic/pharmacodynamic model and response surface analysis: clinical implications for azole-resistant aspergillosis

Polymyxin B in combination with doripenem against heteroresistant Acinetobacter baumannii: pharmacodynamics of new dosing strategies

Resistance suppression by high-intensity, short-duration aminoglycoside exposure against hypermutable and non-hypermutable Pseudomonas aeruginosa

Population pharmacokinetics and pharmacodynamics of teicoplanin in neonates: making better use of C-reactive protein to deliver individualized therapy

Tissue pharmacokinetics of telavancin in healthy volunteers: a microdialysis study

HIV pre-exposure prophylaxis for women and infants prevents vaginal and oral HIV transmission in a preclinical model of HIV infection

IFN-free therapy for HIV/HCV-coinfected patients within the liver transplant setting

HIV-1-RNA in seminal plasma correlates with detection of HIV-1-DNA in semen cells, but not with CMV shedding, among MSM on successful antiretroviral regimens

Levels of bone markers in a population of infants exposed in utero and during breastfeeding to tenofovir within an Option B+ programme in Malawi

Improved adipose tissue function with initiation of protease inhibitor-only ART

High efficacy of first-line ART in a West African cohort, assessed by dried blood spot virological and pharmacological measurements

Virological efficacy of PI monotherapy for HIV-1 in clinical practice

Maraviroc/raltegravir simplification strategy following 6 months of quadruple therapy with tenofovir/emtricitabine/maraviroc/raltegravir in treatment-naive HIV patients

Validation of the mutant selection window hypothesis with fosfomycin against Escherichia coli and Pseudomonas aeruginosa: an in vitro and in vivo comparative study

Validation of the mutant selection window hypothesis with fosfomycin against Escherichia coli and Pseudomonas aeruginosa: an in vitro and in vivo comparative study

The Journal of Antibiotics advance online publication, October 19 2016. doi:10.1038/ja.2016.124

Authors: Ai-jun Pan, Qing Mei, Ying Ye, Hong-ru Li, Bao Liu & Jia-bin Li

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Microbacterium lacusdiani sp. nov., a phosphate-solubilizing novel actinobacterium isolated from mucilaginous sheath of Microcystis

Microbacterium lacusdiani sp. nov., a phosphate-solubilizing novel actinobacterium isolated from mucilaginous sheath of Microcystis

The Journal of Antibiotics advance online publication, October 19 2016. doi:10.1038/ja.2016.125

Authors: Bing-Huo Zhang, Nimaichand Salam, Juan Cheng, Han-Quan Li, Jian-Yuan Yang, Dai-Ming Zha, Qi-Gen Guo & Wen-Jun Li

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Antibiotics in microbial coculture

Antibiotics in microbial coculture

The Journal of Antibiotics advance online publication, October 19 2016. doi:10.1038/ja.2016.127

Authors: Kenji Ueda & Teruhiko Beppu

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Antiviral effect of theaflavins against caliciviruses

Antiviral effect of theaflavins against caliciviruses

The Journal of Antibiotics advance online publication, October 19 2016. doi:10.1038/ja.2016.128

Authors: Mai Ohba, Tomoichiro Oka, Takayuki Ando, Saori Arahata, Asaka Ikegaya, Hirotaka Takagi, Naohisa Ogo, Chelsea Zhu, Kazuhiro Owada, Fumihiko Kawamori, Qiuhong Wang, Linda J Saif & Akira Asai

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Amide compound synthesis by adenylation domain of bacillibactin synthetase

Amide compound synthesis by adenylation domain of bacillibactin synthetase

The Journal of Antibiotics advance online publication, October 12 2016. doi:10.1038/ja.2016.117

Authors: Tomoko Abe, Yoshiteru Hashimoto, Sayaka Sugimoto, Kenta Kobayashi, Takuto Kumano & Michihiko Kobayashi

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Julian Davies and the discovery of kanamycin resistance transposon Tn5

Julian Davies and the discovery of kanamycin resistance transposon Tn5

The Journal of Antibiotics advance online publication, October 12 2016. doi:10.1038/ja.2016.120

Author: Douglas E Berg

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Production of valuable compounds by molds and yeasts

Production of valuable compounds by molds and yeasts

The Journal of Antibiotics advance online publication, October 12 2016. doi:10.1038/ja.2016.121

Authors: Arnold L Demain & Evan Martens

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New isofuranonaphthoquinones and isoindolequinones from Streptomyces sp. CB01883

New isofuranonaphthoquinones and isoindolequinones from Streptomyces sp. CB01883

The Journal of Antibiotics advance online publication, October 12 2016. doi:10.1038/ja.2016.122

Authors: Zhikai Guo, Guohui Pan, Zhengren Xu, Dong Yang, Hindra , Xiangcheng Zhu, Yong Huang, Li-Xing Zhao, Yi Jiang, Yanwen Duan & Ben Shen

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Characterization of the biosynthetic gene cluster (ata) for the A201A aminonucleoside antibiotic from Saccharothrix mutabilis subsp. capreolus

Characterization of the biosynthetic gene cluster (ata) for the A201A aminonucleoside antibiotic from Saccharothrix mutabilis subsp. capreolus

The Journal of Antibiotics advance online publication, October 12 2016. doi:10.1038/ja.2016.123

Authors: Irene Saugar, Brian Molloy, Eloisa Sanz, María Blanca Sánchez, María Fernández-Lobato & Antonio Jiménez

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Synthesis and structure–activity relationships of novel lincomycin derivatives part 3: discovery of the 4-(pyrimidin-5-yl)phenyl group in synthesis of 7(S)-thiolincomycin analogs

Synthesis and structure–activity relationships of novel lincomycin derivatives part 3: discovery of the 4-(pyrimidin-5-yl)phenyl group in synthesis of 7(S)-thiolincomycin analogs

The Journal of Antibiotics advance online publication, October 5 2016. doi:10.1038/ja.2016.114

Authors: Yoshinari Wakiyama, Ko Kumura, Eijiro Umemura, Satomi Masaki, Kazutaka Ueda, Yasuo Sato, Takashi Watanabe, Yoko Hirai & Keiichi Ajito

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Three structurally-related impurities in norvancomycin drug substance

Three structurally-related impurities in norvancomycin drug substance

The Journal of Antibiotics advance online publication, October 5 2016. doi:10.1038/ja.2016.115

Authors: Zhibo Jiang, Xuan Lei, Minghua Chen, Bingya Jiang, Linzhuan Wu, Xuexia Zhang, Zhihui Zheng, Xinxin Hu, Xuefu You, Shuyi Si, Lifei Wang & Bin Hong

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