Antifungal susceptibilities of Candida, Cryptococcus neoformans and Aspergillus fumigatus from the Asia and Western Pacific region: data from the SENTRY antifungal surveillance program (2010–2012)
The Journal of Antibiotics advance online publication, April 22 2015. doi:10.1038/ja.2015.29
Authors: Michael A Pfaller, Shawn A Messer, Ronald N Jones & Mariana Castanheira
Clonoamide, a new inhibitor of sterol O-acyltransferase, produced by Clonostachys sp. BF-0131
The Journal of Antibiotics advance online publication, April 22 2015. doi:10.1038/ja.2015.37
Authors: Keisuke Kobayashi, Nobuaki Tsukasaki, Ryuji Uchida, Yuichi Yamaguchi & Hiroshi Tomoda
Diketopiperazines, inhibitors of sterol O-acyltransferase, produced by a marine-derived Nocardiopsis sp. KM2-16
The Journal of Antibiotics advance online publication, April 22 2015. doi:10.1038/ja.2015.38
Authors: Keisuke Kobayashi, Takashi Fukuda, Takeshi Terahara, Enjuro Harunari, Chiaki Imada & Hiroshi Tomoda
Graphiumins, new thiodiketopiperazines from the marine-derived fungus Graphium sp. OPMF00224
The Journal of Antibiotics advance online publication, April 22 2015. doi:10.1038/ja.2015.41
Authors: Takashi Fukuda, Minori Shinkai, Eri Sasaki, Kenichiro Nagai, Yuko Kurihara, Akihiko Kanamoto & Hiroshi Tomoda
A novel mutation in the vraS gene of Staphylococcus aureus contributes to reduce susceptibility against daptomycin
The Journal of Antibiotics advance online publication, April 22 2015. doi:10.1038/ja.2015.42
Authors: Jie Su, Maki Iehara, Jyunichiro Yasukawa, Yasuhiko Matsumoto, Hiroshi Hamamoto & Kazuhisa Sekimizu
Trichoketides A and B, two new protein tyrosine phosphatase 1B inhibitors from the marine-derived fungus Trichoderma sp.
The Journal of Antibiotics advance online publication, April 22 2015. doi:10.1038/ja.2015.44
Authors: Hiroyuki Yamazaki, Ryo Saito, Ohgi Takahashi, Ryota Kirikoshi, Kengo Toraiwa, Kohei Iwasaki, Yuta Izumikawa, Wataru Nakayama & Michio Namikoshi
Cinatrins D and E, and virgaricin B, three novel compounds produced by a fungus, Virgaria boninensis FKI-4958
The Journal of Antibiotics advance online publication, April 22 2015. doi:10.1038/ja.2015.45
Authors: Takahiro Ishii, Kenichi Nonaka, Akihiro Sugawara, Masato Iwatsuki, Rokuro Masuma, Tomoyasu Hirose, Toshiaki Sunazuka, Satoshi Ōmura & Kazuro Shiomi
The role of antimicrobial pharmacists has changed considerably over the past 15 years. We describe here the development and ratification of a new expert professional curriculum to guide the training and development of antimicrobial specialist pharmacists. The curriculum has been developed by the UK Clinical Pharmacy Association Pharmacy Infection Network and endorsed by the Royal Pharmaceutical Society as a tool to support pharmacists in meeting the requirements for joining the Royal Pharmaceutical Society Faculty. This new resource has also been endorsed by PHE, the Scottish Antimicrobial Prescribing Group and the BSAC, and will support antimicrobial pharmacists in delivery of antimicrobial stewardship, which will in turn help the fight against antimicrobial resistance.
Drug licensing is changing. Previously, regulators prioritized the licensing of innovative drugs that fulfilled a high unmet medical need for a small number of patients, including orphan, cancer and HIV medicines. Alternatives to large and costly prospective, randomized, double-blind clinical trials have led to a more bespoke development, such as adaptive design studies. Regulators have recently agreed to include much-needed narrow-spectrum antibiotics, active against certain MDR bacteria, in this paradigm. The background to why big pharmaceutical companies have largely deserted the antibacterial research arena, and the proposals that are hoped to reinvigorate their interest, are presented.
TB, caused by Mycobacterium tuberculosis, is one the leading infectious diseases worldwide. There is an urgent need to discover new drugs with unique structures and uncommon mechanisms of action to treat M. tuberculosis and combat antimycobacterial resistance. Naturally occurring compounds contain a wide diversity of chemical structures, displaying a wide range of in vitro potency towards M. tuberculosis. A number of recent studies have shown that natural antimycobacterial peptides can disrupt the function of the mycobacterial cell wall through different modes of action and thereafter interact with intracellular targets, including nucleic acids, enzymes and even organelles. More importantly, the probability of antimycobacterial resistance is low. This review presents several natural antimicrobial peptides isolated from different organism sources, including bacteria, fungi, plants and animals. In addition, the molecular features of these molecules are the subject of much attention. Such peptides have common traits among their chemical features, which may be correlated with their biological activities; hence, different parts of the molecular structures can be modified in order to increase penetration into the target cells. This review also summarizes the available information on the properties of antimycobacterial peptides associated with their biological activities.
Investigation of the molecular epidemiology of Acinetobacter baumannii isolated from patients and environmental contamination
The Journal of Antibiotics advance online publication, April 15 2015. doi:10.1038/ja.2015.30
Authors: Chunmei Ying, Yongli Li, Yaping Wang, Bing Zheng & Chengde Yang
Structural biological study of self-resistance determinants in antibiotic-producing actinomycetes
The Journal of Antibiotics advance online publication, April 15 2015. doi:10.1038/ja.2015.32
Author: Masanori Sugiyama
Two new anthraquinones from the soil fungus Penicillium purpurogenum SC0070
The Journal of Antibiotics advance online publication, April 15 2015. doi:10.1038/ja.2015.35
Authors: Jinghua Xue, Ying Fu, Ping Wu, Liangxiong Xu, Riming Huang, Xiaoyi Wei & Hanxiang Li
Reactivation of antibiosis in the entomogenous fungus Chrysoporthe sp. SNB-CN74
The Journal of Antibiotics advance online publication, April 15 2015. doi:10.1038/ja.2015.36
Authors: Charlotte Nirma, Véronique Eparvier & Didier Stien
Liamocin oil from Aureobasidium pullulans has antibacterial activity with specificity for species of Streptococcus
The Journal of Antibiotics advance online publication, April 15 2015. doi:10.1038/ja.2015.39
Authors: Kenneth M Bischoff, Timothy D Leathers, Neil PJ Price & Pennapa Manitchotpisit
Antimicrobial resistance surveillance of doripenem in China
The Journal of Antibiotics advance online publication, April 8 2015. doi:10.1038/ja.2015.25
Authors: Yun Li, Yuan Lv, Feng Xue, Bo Zheng, Jian Liu & Jia Zhang
Association of overexpression of efflux pump genes with antibiotic resistance in Pseudomonas aeruginosa strains clinically isolated from urinary tract infection patients
The Journal of Antibiotics advance online publication, April 8 2015. doi:10.1038/ja.2015.34
Authors: Katsumi Shigemura, Kayo Osawa, Ayaka Kato, Issei Tokimatsu, Soichi Arakawa, Toshiro Shirakawa & Masato Fujisawa
