Isolation and structure elucidation of new phthalide and phthalane derivatives, isolated as antimicrobial agents from Emericella sp. IFM57991
The Journal of Antibiotics advance online publication, August 26 2015. doi:10.1038/ja.2015.85
Authors: Tetsuya Saito, Takeshi Itabashi, Daigo Wakana, Hisashi Takeda, Takashi Yaguchi, Ken-ichi Kawai & Tomoo Hosoe
Verrulactones D and E with unprecedented skeletons, new inhibitors of Staphylococcus aureus enoyl-ACP reductase, from Penicillium verruculosum F375
The Journal of Antibiotics advance online publication, August 26 2015. doi:10.1038/ja.2015.86
Authors: Nyung Kim, Mi-Jin Sohn, Hiroyuki Koshino & Won-Gon Kim
Zincmethylphyrins and coproporphyrins, novel growth factors released by Sphingopyxis sp., enable laboratory cultivation of previously uncultured Leucobacter sp. through interspecies mutualism
The Journal of Antibiotics advance online publication, August 26 2015. doi:10.1038/ja.2015.87
Authors: Mohammad Nazrul Islam Bhuiyan, Ryogo Takai, Shinya Mitsuhashi, Kengo Shigetomi, Yasuhiro Tanaka, Yoichi Kamagata & Makoto Ubukata
Structure and activity relationships of the anti-Mycobacterium antibiotics resorcinomycin and pheganomycin
The Journal of Antibiotics advance online publication, August 26 2015. doi:10.1038/ja.2015.88
Authors: Yasushi Ogasawara, Koichi Ooya, Michiko Fujimori, Motoyoshi Noike & Tohru Dairi
Absolute configuration of NFAT-133, an aromatic polyketide with immunosuppressive and antidiabetic activity from actinomycetes
The Journal of Antibiotics advance online publication, August 19 2015. doi:10.1038/ja.2015.80
Authors: Yanan Yang, Linkai Yu, Hisayuki Komaki, Naoya Oku & Yasuhiro Igarashi
Antimicrobial susceptibility testing with phenotypic methods is based on the measurement of the MIC (mg/L) and breakpoints to categorize bacteria and fungi as susceptible, intermediate or resistant. Phenotypic antimicrobial susceptibility testing requires an agreement on breakpoints and a rigorous standardization of methods and materials. Requirements for defining breakpoints include a definition of doses and dose intervals, information on MIC distributions for the target organisms, definitions of the highest MIC for organisms devoid of phenotypically expressed resistance (the epidemiological cut-off) and information on resistance mechanisms, pharmacokinetics, pharmacodynamics and clinical outcome in trials. In 2001, the breakpoint committees of France, Germany, Norway, Sweden, the Netherlands and the UK were tasked with developing European breakpoints under the umbrella of EUCAST, organized by ESCMID and later also by ECDC. Breakpoints for previously established antibacterial and antifungal agents in Europe have now been harmonized. With the EMA, EUCAST has since 2006 determined breakpoints for new agents. All breakpoints are freely available on the EUCAST web site; these are used in semi-automated antimicrobial susceptibility testing devices and have been employed since 2010 in a EUCAST disc diffusion method. They have been or are now being implemented in most countries inside Europe and many countries outside it. Everything needed to perform and interpret antimicrobial susceptibility testing is freely available from the EUCAST web site, as are aggregated MIC distributions based on more than 26 000 distributions.
