mercredi 11 mai 2016

DNA sequence-selective C8-linked pyrrolobenzodiazepine–heterocyclic polyamide conjugates show anti-tubercular-specific activities

DNA sequence-selective C8-linked pyrrolobenzodiazepine–heterocyclic polyamide conjugates show anti-tubercular-specific activities

The Journal of Antibiotics advance online publication, May 11 2016. doi:10.1038/ja.2016.43

Authors: Federico Brucoli, Juan D Guzman, Mohammad A Basher, Dimitrios Evangelopoulos, Eleanor McMahon, Tulika Munshi, Timothy D McHugh, Keith R Fox & Sanjib Bhakta



from The Journal of Antibiotics - AOP - nature.com science feeds http://ift.tt/1rFE2Vh

Pseudopyronine B, an inhibitor of sterol O-acyltransferase, produced by Pseudomonas sp. BYK11209

Pseudopyronine B, an inhibitor of sterol O-acyltransferase, produced by Pseudomonas sp. BYK11209

The Journal of Antibiotics advance online publication, May 11 2016. doi:10.1038/ja.2016.46

Authors: Aika Suzuki, Takashi Fukuda, Keisuke Kobayashi, Taichi Ohshiro & Hiroshi Tomoda



from The Journal of Antibiotics - AOP - nature.com science feeds http://ift.tt/1rFE2Vb

Kinetic characterization of GES-22 β-lactamase harboring the M169L clinical mutation

Kinetic characterization of GES-22 β-lactamase harboring the M169L clinical mutation

The Journal of Antibiotics advance online publication, May 11 2016. doi:10.1038/ja.2016.48

Authors: Aysegul Saral, David A Leonard, Azer Ozad Duzgun, Aysegul Copur Cicek, Cynthia M June & Cemal Sandalli



from The Journal of Antibiotics - AOP - nature.com science feeds http://ift.tt/1rFE2V8

Quantitative measurement of the outer membrane permeability in Escherichia coli lpp and tol–pal mutants defines the significance of Tol–Pal function for maintaining drug resistance

Quantitative measurement of the outer membrane permeability in Escherichia coli lpp and tol–pal mutants defines the significance of Tol–Pal function for maintaining drug resistance

The Journal of Antibiotics advance online publication, May 11 2016. doi:10.1038/ja.2016.50

Authors: Hikaru Kowata, Saeko Tochigi, Tomonobu Kusano & Seiji Kojima



from The Journal of Antibiotics - AOP - nature.com science feeds http://ift.tt/1rFE4fP

mardi 26 avril 2016

Recognition of acyl carrier proteins by ketoreductases in assembly line polyketide synthases

Recognition of acyl carrier proteins by ketoreductases in assembly line polyketide synthases

The Journal of Antibiotics advance online publication, April 27 2016. doi:10.1038/ja.2016.41

Authors: Matthew P Ostrowski, David E Cane & Chaitan Khosla



from The Journal of Antibiotics - AOP - nature.com science feeds http://ift.tt/1qSwAW7

Synthesis and antibacterial activity of novel 11-[3-[(arylcarbamoyl)oxy]propylamino]-11-deoxy-6-O-methyl-3-oxoerythromycin A 11-N,12-O-cyclic carbamate derivatives

Synthesis and antibacterial activity of novel 11-[3-[(arylcarbamoyl)oxy]propylamino]-11-deoxy-6-O-methyl-3-oxoerythromycin A 11-N,12-O-cyclic carbamate derivatives

The Journal of Antibiotics advance online publication, April 27 2016. doi:10.1038/ja.2016.42

Authors: Zhonghui Zheng, Deping Du, Lili Cao, Jun Liu & Xiaofang Chen



from The Journal of Antibiotics - AOP - nature.com science feeds http://ift.tt/1qSwC09