Determinants of virological failure and antiretroviral drug resistance in Mozambique

Actinoplanes bogoriensis sp. nov., a novel actinomycete isolated from leaf litter

Actinoplanes bogoriensis sp. nov., a novel actinomycete isolated from leaf litter

The Journal of Antibiotics advance online publication, August 5 2015. doi:10.1038/ja.2015.81

Authors: Arif Nurkanto, Puspita Lisdiyanti, Moriyuki Hamada, Shanti Ratnakomala, Chiyo Shibata & Tomohiko Tamura

from The Journal of Antibiotics - AOP - nature.com science feeds http://ift.tt/1MM1mZa

Penicyrones A and B, an epimeric pair of α-pyrone-type polyketides produced by the marine-derived Penicillium sp.

Penicyrones A and B, an epimeric pair of α-pyrone-type polyketides produced by the marine-derived Penicillium sp.

The Journal of Antibiotics advance online publication, August 5 2015. doi:10.1038/ja.2015.82

Authors: Ying-Yue Bu, Hiroyuki Yamazaki, Ohgi Takahashi, Ryota Kirikoshi, Kazuyo Ukai & Michio Namikoshi

from The Journal of Antibiotics - AOP - nature.com science feeds http://ift.tt/1OPuV9Q

Phenolic compounds from the fungus Inonotus obliquus and their antioxidant properties

Phenolic compounds from the fungus Inonotus obliquus and their antioxidant properties

The Journal of Antibiotics advance online publication, July 29 2015. doi:10.1038/ja.2015.83

Authors: Byung Soon Hwang, In-Kyoung Lee & Bong-Sik Yun

from The Journal of Antibiotics - AOP - nature.com science feeds http://ift.tt/1fFRn9K

Biological evaluation and determination of the absolute configuration of chloromonilicin, a strong antimicrobial metabolite isolated from Alternaria sonchi

Biological evaluation and determination of the absolute configuration of chloromonilicin, a strong antimicrobial metabolite isolated from Alternaria sonchi

The Journal of Antibiotics advance online publication, July 15 2015. doi:10.1038/ja.2015.74

Authors: Alessio Cimmino, Gennaro Pescitelli, Alexander Berestetskiy, Anna Dalinova, Denis Krivorotov, Angela Tuzi & Antonio Evidente

from The Journal of Antibiotics - AOP - nature.com science feeds http://ift.tt/1K6UX7q

Three novel polyene macrolides isolated from cultures of Streptomyces lavenduligriseus

Three novel polyene macrolides isolated from cultures of Streptomyces lavenduligriseus

The Journal of Antibiotics advance online publication, July 15 2015. doi:10.1038/ja.2015.76

Authors: Jiayue Yang, Zhijun Yang, Yu Yin, Min Rao, Yongheng Liang & Mei Ge

from The Journal of Antibiotics - AOP - nature.com science feeds http://ift.tt/1I1v9f6

Reviving old antibiotics

In the face of increasing antimicrobial resistance and the paucity of new antimicrobial agents it has become clear that new antimicrobial strategies are urgently needed. One of these is to revisit old antibiotics to ensure that they are used correctly and to their full potential, as well as to determine whether one or several of them can help alleviate the pressure on more recent agents. Strategies are urgently needed to ‘re-develop’ these drugs using modern standards, integrating new knowledge into regulatory frameworks and communicating the knowledge from the research bench to the bedside. Without a systematic approach to re-developing these old drugs and rigorously testing them according to today's standards, there is a significant risk of doing harm to patients and further increasing multidrug resistance. This paper describes factors to be considered and outlines steps and actions needed to re-develop old antibiotics so that they can be used effectively for the treatment of infections.

from Journal of Antimicrobial Chemotherapy - current issue http://ift.tt/1HEmCZg
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